Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDAH1 | O94760 | 5/20 | 0.44 |
| ▸ | ARG1 | P05089 | 4/20 | 0.40 |
| ▸ | ARG2 | P78540 | 2/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1343529 | 0.74 | DDAH1 (0.53) | DDAH1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1345153 | 0.71 | DDAH1 (0.52) | DDAH1NOS1NOS2NOS3 | |
| SCHEMBL1345488 | 0.69 | DDAH1 (0.73) | DDAH1NOS1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL1345420 | 0.69 | DDAH1 (0.47) | DDAH1NOS1NOS2GRIN2DGRIN3B | |
| SCHEMBL16363209 | 0.68 | DDAH1 (0.76) | DDAH1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1343488 | 0.66 | DDAH1 (0.43) | DDAH1NOS1NOS2GRIN2DGRIN3B | |
| SCHEMBL1345585 | 0.65 | DDAH1 (0.48) | DDAH1NOS1NOS2GRIN2DGRIN3B | |
| SCHEMBL1345052 | 0.65 | DDAH1 (0.43) | DDAH1NOS1NOS2GRIN2DGRIN3B | |
| SCHEMBL1343296 | 0.65 | DDAH1 (0.43) | DDAH1NOS1NOS2GRIN2DGRIN3B | |
| SCHEMBL1916741 | 0.64 | ARG1 (0.45) | ARG1ARG2NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063104-B2 | Guanidine derivatives as inhibitors of DDAH | UCL BUSINESS PLC (GB) | 2011-11-22 | — | — | US | disclosed |