Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.50 |
| ▸ | CDC42BPA | Q5VT25 | 4/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1987445 | 0.90 | LMNA (0.57) | TP53LMNAMAPTPOLBROCK2 | |
| SCHEMBL1986880 | 0.84 | ROCK2 (0.75) | ROCK2ROCK1CDC42BPARPS6KB1 | |
| SCHEMBL13457441 | 0.84 | LMNA (0.66) | TP53LMNAMAPTPOLBROCK2 | |
| SCHEMBL1986458 | 0.84 | ROCK2 (0.69) | TP53LMNAMAPTPOLBROCK2 | |
| SCHEMBL12562339 | 0.82 | ROCK2 (0.71) | ROCK2ROCK1CDC42BPARPS6KB1 | |
| SCHEMBL12602025 | 0.79 | ROCK2 (0.67) | ROCK2ROCK1CDC42BPARPS6KB1 | |
| SCHEMBL12562095 | 0.79 | TP53 (0.77) | TP53LMNAMAPTPOLBROCK2 | |
| SCHEMBL1984889 | 0.74 | ROCK2 (0.75) | ROCK2ROCK1CDC42BPARPS6KB1 | |
| SCHEMBL12562389 | 0.74 | ROCK2 (0.76) | TP53LMNAMAPTROCK2ROCK1 | |
| SCHEMBL1987125 | 0.73 | ROCK2 (0.68) | TP53LMNAMAPTROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010024903-A1 | BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-03-04 | — | — | WO | disclosed |