Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 5/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.61 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.54 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1986458 | 0.92 | ROCK2 (0.69) | LMNATP53POLBMAPTROCK2 | |
| SCHEMBL12562095 | 0.86 | TP53 (0.77) | LMNATP53POLBMAPTROCK2 | |
| SCHEMBL13457193 | 0.84 | TP53 (0.58) | LMNATP53POLBMAPTROCK2 | |
| SCHEMBL1987445 | 0.84 | LMNA (0.57) | LMNATP53POLBMAPTROCK2 | |
| SCHEMBL13456995 | 0.82 | LMNA (0.58) | LMNATP53POLBMAPTROCK2 | |
| SCHEMBL1986785 | 0.82 | ROCK2 (0.86) | ROCK2RPS6KB1ROCK1CDC42BPA | |
| SCHEMBL1987655 | 0.80 | ROCK2 (0.64) | LMNATP53MAPTROCK2RPS6KB1 | |
| SCHEMBL12756749 | 0.79 | TP53 (0.56) | LMNATP53POLBMAPTROCK2 | |
| SCHEMBL1988309 | 0.78 | ROCK2 (0.60) | LMNATP53MAPTROCK2RPS6KB1 | |
| SCHEMBL12602331 | 0.78 | TP53 (0.71) | LMNATP53POLBMAPTROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010024903-A1 | BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-03-04 | — | — | WO | disclosed |