Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | CCR1 | P32246 | 2/20 | 0.68 |
| ▸ | CCR5 | P51681 | 2/20 | 0.68 |
| ▸ | CCR8 | P51685 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | METAP1 | P53582 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.68 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.68 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.68 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | TP53 | P04637 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29984274 | 1.00 | KDM4E (0.68) | KDM4ELMNACYP1A2CCR1CCR5 | |
| SCHEMBL30989132 | 0.97 | KDM4E (0.72) | KDM4ELMNACYP1A2CCR1CCR5 | |
| SCHEMBL1566968 | 0.97 | KDM4E (0.72) | KDM4ELMNACYP1A2CCR1CCR5 | |
| SCHEMBL30989133 | 0.97 | KDM4E (0.72) | KDM4ELMNACYP1A2CCR1CCR5 | |
| SCHEMBL29730352 | 0.95 | KDM4E (0.62) | KDM4ELMNACYP1A2CCR1CCR5 | |
| SCHEMBL21173034 | 0.95 | KDM4E (0.62) | KDM4ELMNACYP1A2CCR1CCR5 | |
| SCHEMBL750061 | 0.95 | KDM4E (0.62) | KDM4ELMNACYP1A2CCR1CCR5 | |
| SCHEMBL14293722 | 0.93 | KDM4E (0.59) | KDM4ELMNACYP1A2CCR1CCR5 | |
| SCHEMBL17951533 | 0.93 | KDM4E (0.59) | KDM4ELMNACYP1A2CCR1CCR5 | |
| SCHEMBL27635174 | 0.93 | KDM4E (0.59) | KDM4ELMNACYP1A2CCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168576-A2 | New utilities of tricyclic compounds | Shionogi & Co., Ltd. (JP) | 2010-03-31 | — | — | EP | disclosed |
| US-20080318958-A1 | New utilities of tricyclic compounds | ISHIZUKA NATSUKI | 2008-12-25 | — | — | US | disclosed |
| US-20080318958-A1 | New utilities of tricyclic compounds | ISHIZUKA NATSUKI | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318958-A1 | New utilities of tricyclic compounds | APOB, PON1, APOL1 | KDM4E 4138/4885LMNA 920/4885CYP1A2 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.