Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.43 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.42 |
| ▸ | CLK1 | P49759 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12742728 | 0.91 | DYRK1A (0.46) | PRKCIDYRK1ADYRK1BDYRK2SLC6A2 | |
| SCHEMBL12742724 | 0.77 | MAOB (0.44) | DYRK1ADYRK1BDYRK2CLK1MAPT | |
| SCHEMBL19264977 | 0.76 | PRKCI (0.43) | PRKCIDYRK1ADYRK1BDYRK2SLC6A2 | |
| SCHEMBL13365167 | 0.76 | SLC6A2 (0.46) | PRKCISLC6A2SLC6A4HDAC3HDAC4 | |
| SCHEMBL21907080 | 0.75 | PRKCI (0.45) | PRKCIDYRK1ADYRK1BDYRK2SLC6A2 | |
| SCHEMBL17656334 | 0.75 | ERN1 (0.44) | PRKCIDYRK1ADYRK1BDYRK2SLC6A2 | |
| SCHEMBL1465591 | 0.73 | SLC6A2 (0.44) | PRKCISLC6A2SLC6A4HDAC3HDAC4 | |
| SCHEMBL19753163 | 0.73 | LMNA (0.53) | SLC6A2SLC6A4MAPT | |
| SCHEMBL104120 | 0.72 | LMNA (0.47) | DYRK1ADYRK1BDYRK2SLC6A2SLC6A4 | |
| SCHEMBL8806322 | 0.72 | DRD2 (0.46) | PRKCIDYRK1ADYRK1BDYRK2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1589029-B1 | Pyrazinone protease inhibitors | ORTHO MCNEIL PHARM INC (US) | 2010-03-17 | — | — | EP | disclosed |