Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.42 |
| ▸ | FASN | P49327 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL348308 | 0.89 | ACKR3 (0.44) | L3MBTL1ACKR3FASNEPHX2NPC1 | |
| SCHEMBL348806 | 0.88 | L3MBTL1 (0.44) | L3MBTL1ACKR3FASNEPHX2NPC1 | |
| SCHEMBL348309 | 0.88 | KDM5C (0.45) | L3MBTL1ACKR3FASNEPHX2NPC1 | |
| SCHEMBL347706 | 0.86 | ACKR3 (0.43) | L3MBTL1ACKR3FASNEPHX2NPC1 | |
| SCHEMBL347188 | 0.78 | ALDH1A1 (0.44) | L3MBTL1ACKR3FASNEPHX2NPC1 | |
| SCHEMBL13663360 | 0.78 | NPC1 (0.39) | L3MBTL1FASNEPHX2NPC1POLB | |
| SCHEMBL347273 | 0.77 | ALDH1A1 (0.43) | L3MBTL1ACKR3FASNEPHX2NPC1 | |
| SCHEMBL13663431 | 0.77 | TSHR (0.44) | L3MBTL1ACKR3RAB9AALDH1A1KMT2A | |
| SCHEMBL347099 | 0.77 | PRKAA2 (0.44) | L3MBTL1ACKR3EPHX2PRKAB2PRKAG1 | |
| SCHEMBL347189 | 0.77 | ALDH1A1 (0.46) | L3MBTL1ACKR3EPHX2NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010025179-A1 | 1-(4-UREIDOBENZOYL)PIPERAZINE DERIVATIVES | N.V. ORGANON (NL) | 2010-03-04 | — | — | WO | disclosed |