Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5C | P41229 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | FASN | P49327 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL348308 | 0.91 | ACKR3 (0.44) | ACKR3NPC1POLBRAB9AL3MBTL1 | |
| SCHEMBL348806 | 0.90 | L3MBTL1 (0.44) | ACKR3NPC1POLBRAB9AL3MBTL1 | |
| SCHEMBL13458595 | 0.88 | L3MBTL1 (0.42) | ACKR3NPC1POLBRAB9AL3MBTL1 | |
| SCHEMBL347706 | 0.88 | ACKR3 (0.43) | ACKR3NPC1POLBRAB9AL3MBTL1 | |
| SCHEMBL347189 | 0.85 | ALDH1A1 (0.46) | ACKR3NPC1POLBRAB9AL3MBTL1 | |
| SCHEMBL346659 | 0.81 | NPC1 (0.56) | NPC1POLBRAB9AL3MBTL1FASN | |
| SCHEMBL347188 | 0.80 | ALDH1A1 (0.44) | ACKR3NPC1POLBRAB9AL3MBTL1 | |
| SCHEMBL347273 | 0.79 | ALDH1A1 (0.43) | ACKR3NPC1POLBRAB9AL3MBTL1 | |
| SCHEMBL347099 | 0.79 | PRKAA2 (0.44) | ACKR3L3MBTL1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL348551 | 0.78 | L3MBTL1 (0.41) | NPC1POLBRAB9AL3MBTL1FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8759352-B2 | 1-(4-ureidobenzoyl)piperazine derivatives | MERCK SHARP & DOHME B.V. (NL) | 2014-06-24 | — | — | US | disclosed |
| EP-2318368-B1 | 1-(4-UREIDOBENZOYL)PIPERAZINE DERIVATIVES | MERCK SHARP & DOHME (NL) | 2013-10-16 | — | — | EP | disclosed |
| US-20120015958-A1 | 1-(4-UREIDOBENZOYL)PIPERAZINE DERIVATIVES | N.V. ORGANON (NL) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015958-A1 | 1-(4-UREIDOBENZOYL)PIPERAZINE DERIVATIVES | NPC1, ABCB11, NPC1L1 | KDM5C 2635/4885KDM4C 3551/4885ACKR3 1675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.