Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 5/20 | 0.45 |
| ▸ | INSR | P06213 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | TEK | Q02763 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 2/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2203299 | 0.83 | TGFBR1 (0.57) | TGFBR1PRKD1KDRINSRCSF1R | |
| SCHEMBL2207615 | 0.78 | TGFBR1 (0.49) | TGFBR1PRKD1KDRINSRCSF1R | |
| SCHEMBL12430714 | 0.78 | AURKA (0.70) | TGFBR1PRKD1AURKASRCGSK3B | |
| SCHEMBL12045474 | 0.76 | NPY5R (0.49) | TGFBR1PRKD1KDRINSRCSF1R | |
| SCHEMBL7151882 | 0.74 | AURKA (0.59) | AURKASRCGSK3BMERTKNPY5R | |
| SCHEMBL12430681 | 0.73 | ULK1 (0.69) | KDRCSF1RAURKASRCGSK3B | |
| SCHEMBL2202540 | 0.72 | AURKA (0.50) | AURKASRCGSK3BMERTKNPY5R | |
| SCHEMBL13938217 | 0.71 | GSK3B (0.57) | AURKASRCGSK3B | |
| SCHEMBL3757345 | 0.69 | AURKA (0.43) | AURKASRCGSK3BMERTKNPY5R | |
| SCHEMBL27595549 | 0.68 | CASP6 (0.54) | AURKANPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010031056-A2 | METHODS AND COMPOSITIONS FOR MODULATING IRE1, SRC, AND ABL ACTIVITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-03-18 | — | — | WO | disclosed |