Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13461041 | 0.95 | LMNA (0.46) | LMNAROCK2ROCK1RECQLPOLB | |
| SCHEMBL13460875 | 0.92 | ROCK2 (0.45) | LMNAROCK2ROCK1RECQLPOLB | |
| SCHEMBL13461038 | 0.92 | FLT1 (0.44) | LMNAROCK2ROCK1RECQLPOLB | |
| SCHEMBL13460877 | 0.89 | ROCK2 (0.41) | LMNAROCK2ROCK1RECQLPOLB | |
| SCHEMBL13460821 | 0.86 | PPARG (0.46) | LMNAROCK2ROCK1RECQLPOLB | |
| SCHEMBL3411792 | 0.85 | ACLY (0.48) | LMNAROCK2ROCK1RECQLPOLB | |
| SCHEMBL13460781 | 0.85 | LMNA (0.45) | LMNAROCK2ROCK1RECQLPOLB | |
| SCHEMBL13460881 | 0.85 | HPGD (0.45) | LMNAROCK2ROCK1RECQLPOLB | |
| SCHEMBL13460827 | 0.85 | LMNA (0.46) | LMNAROCK2ROCK1RECQLTHRB | |
| SCHEMBL3416041 | 0.84 | LMNA (0.50) | LMNAROCK2ROCK1RECQLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |