Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 16/20 | 0.49 |
| ▸ | HTR2A | P28223 | 16/20 | 0.49 |
| ▸ | HTR1A | P08908 | 15/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.49 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.48 |
| ▸ | MST1R | Q04912 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216502 | 0.88 | AURKA (0.46) | CLK4KDRNTRK1FLT3GSK3B | |
| SCHEMBL4728027 | 0.85 | DRD2 (0.52) | DRD2HTR2AHTR1AKCNH2NTRK2 | |
| SCHEMBL4727033 | 0.84 | DRD2 (0.53) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL13027971 | 0.81 | DRD2 (0.47) | DRD2HTR2AHTR1AKCNH2NTRK2 | |
| SCHEMBL16519650 | 0.80 | DRD2 (0.46) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL4505901 | 0.78 | GSTP1 (0.49) | DRD2HTR2AHTR1AKCNH2NTRK2 | |
| SCHEMBL13027989 | 0.76 | AURKA (0.59) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL2849831 | 0.76 | PDE3B (0.53) | NTRK2TYRO3CLK4DYRK1BKDR | |
| SCHEMBL15553470 | 0.76 | NTRK2 (0.51) | DRD2HTR2AHTR1AKCNH2NTRK2 | |
| SCHEMBL31069587 | 0.76 | PDE3B (0.53) | NTRK2TYRO3CLK4DYRK1BKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687527-B2 | Compounds for the treatment of inflammatory disorders | SCHERING CORPORATION (US) | 2010-03-30 | — | — | US | disclosed |
| WO-2007084415-A2 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2007-07-26 | — | — | WO | disclosed |