Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 19/20 | 0.52 |
| ▸ | HTR2A | P28223 | 19/20 | 0.52 |
| ▸ | HTR1A | P08908 | 18/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.48 |
| ▸ | MST1R | Q04912 | 1/20 | 0.48 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.48 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727033 | 0.95 | DRD2 (0.53) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL4728129 | 0.88 | GRM5 (0.42) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL1037269 | 0.85 | DRD2 (0.56) | DRD2 | |
| SCHEMBL13462020 | 0.85 | DRD2 (0.49) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL4729073 | 0.84 | DRD2 (0.43) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL1038435 | 0.81 | DRD2 (0.57) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL13027971 | 0.81 | DRD2 (0.47) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL16519650 | 0.80 | DRD2 (0.46) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL4505901 | 0.78 | GSTP1 (0.49) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL1036450 | 0.77 | KCNA5 (0.53) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020306-A2 | ISOINDOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |