Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 5/20 | 0.73 |
| ▸ | DRD2 | P14416 | 5/20 | 0.73 |
| ▸ | HRH1 | P35367 | 5/20 | 0.73 |
| ▸ | DRD3 | P35462 | 5/20 | 0.73 |
| ▸ | MAPT | P10636 | 4/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.73 |
| ▸ | LMNA | P02545 | 4/20 | 0.73 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.73 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.73 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.73 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.73 |
| ▸ | HTR2A | P28223 | 4/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.73 |
| ▸ | HTR2B | P41595 | 4/20 | 0.73 |
| ▸ | TP53 | P04637 | 4/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.73 |
| ▸ | HTR2C | P28335 | 3/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiopropazate SCHEMBL144729 | 0.92 | MAPT (0.72) | CYP2D6DRD2HRH1DRD3MAPT | |
| Thiopropazate SCHEMBL955965 | 0.91 | MAPT (0.70) | CYP2D6DRD2HRH1DRD3MAPT | |
| Thiopropazate SCHEMBL31153316 | 0.91 | MAPT (0.70) | CYP2D6DRD2HRH1DRD3MAPT | |
| Thiopropazate SCHEMBL955966 | 0.91 | MAPT (0.70) | CYP2D6DRD2HRH1DRD3MAPT | |
| Thiopropazate SCHEMBL1651297 | 0.90 | MAPT (0.69) | CYP2D6DRD2HRH1DRD3MAPT | |
| SCHEMBL10084511 | 0.90 | DRD2 (0.69) | CYP2D6DRD2HRH1DRD3MAPT | |
| Thiopropazate SCHEMBL5972306 | 0.89 | DRD2 (0.77) | CYP2D6DRD2HRH1DRD3MAPT | |
| SCHEMBL1041510 | 0.89 | DRD2 (0.68) | CYP2D6DRD2HRH1DRD3MAPT | |
| SCHEMBL10084508 | 0.88 | DRD2 (0.67) | CYP2D6DRD2HRH1DRD3MAPT | |
| SCHEMBL10084512 | 0.88 | DRD2 (0.66) | CYP2D6DRD2HRH1DRD3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100068786-A1 | METHODS AND COMPOSITIONS FOR REVERSING P-GLYCOPROTEIN MEDICATED DRUG RESISTANCE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100068786-A1 | METHODS AND COMPOSITIONS FOR REVERSING P-GLYCOPROTEIN MEDICATED DRUG RESISTANCE | ABCC1, ABCB1, ABCG2 | CYP2D6 183/4885DRD2 4644/4885HRH1 4283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.