Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.67 |
| ▸ | HRH1 | P35367 | 7/20 | 0.67 |
| ▸ | DRD3 | P35462 | 7/20 | 0.67 |
| ▸ | DRD1 | P21728 | 6/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 5/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.67 |
| ▸ | HTR2A | P28223 | 5/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.67 |
| ▸ | TP53 | P04637 | 4/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.67 |
| ▸ | HTR2B | P41595 | 4/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.67 |
| ▸ | HTR1A | P08908 | 4/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10084512 | 0.95 | DRD2 (0.66) | DRD2HRH1DRD3DRD1MAPT | |
| SCHEMBL31648578 | 0.94 | DRD2 (0.63) | DRD2HRH1DRD3DRD1MAPT | |
| SCHEMBL10084511 | 0.93 | DRD2 (0.69) | DRD2HRH1DRD3DRD1MAPT | |
| Perphenazine 4-Aminobutyrate SCHEMBL8250036 | 0.90 | DRD2 (0.64) | DRD2HRH1DRD3DRD1MAPT | |
| SCHEMBL13602784 | 0.89 | DRD2 (0.62) | DRD2HRH1DRD3DRD1MAPT | |
| Perphenazine 4-Aminobutyrate SCHEMBL29414098 | 0.89 | DRD2 (0.63) | DRD2HRH1DRD3DRD1MAPT | |
| Thiopropazate SCHEMBL144729 | 0.89 | MAPT (0.72) | DRD2HRH1DRD3DRD1MAPT | |
| SCHEMBL13464239 | 0.88 | CYP2D6 (0.73) | DRD2HRH1DRD3DRD1MAPT | |
| SCHEMBL10084510 | 0.88 | HRH1 (0.62) | DRD2HRH1DRD3DRD1MAPT | |
| Thiopropazate SCHEMBL955966 | 0.88 | MAPT (0.70) | DRD2HRH1DRD3DRD1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120309748-A1 | CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF | BAR-ILAN UNIVERSITY (IL) | 2012-12-06 | — | — | US | disclosed |
| US-20120309748-A1 | CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF | BAR-ILAN UNIVERSITY (IL) | 2012-12-06 | — | — | US | disclosed |
| US-8283381-B2 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2012-10-09 | — | — | US | disclosed |
| US-8283381-B2 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2012-10-09 | — | — | US | disclosed |
| US-8168628-B2 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2012-05-01 | — | — | US | disclosed |
| US-8168628-B2 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2012-05-01 | — | — | US | disclosed |
| US-7939525-B2 | Conjugated psychotropic drugs and uses thereof | BAR-ILAN UNIVERSITY (IL) | 2011-05-10 | — | — | US | disclosed |
| US-7939525-B2 | Conjugated psychotropic drugs and uses thereof | BAR-ILAN UNIVERSITY (IL) | 2011-05-10 | — | — | US | disclosed |
| US-20100204469-A1 | CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2010-08-12 | — | — | US | disclosed |
| US-20100204469-A1 | CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2010-08-12 | — | — | US | disclosed |
| US-7598239-B2 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2009-10-06 | — | — | US | disclosed |
| US-7598239-B2 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2009-10-06 | — | — | US | disclosed |
| US-7544681-B2 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2009-06-09 | — | — | US | disclosed |
| US-7544681-B2 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2009-06-09 | — | — | US | disclosed |
| US-20080108606-A1 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2008-05-08 | — | — | US | disclosed |
| US-20080108606-A1 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2008-05-08 | — | — | US | disclosed |
| US-20070197514-A1 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2007-08-23 | — | — | US | disclosed |
| US-20070197514-A1 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2007-08-23 | — | — | US | disclosed |
| US-20070099977-A1 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2007-05-03 | — | — | US | disclosed |
| US-20070099977-A1 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099977-A1 | Conjugated psychotropic drugs and uses thereof | SLC18A2, SLC6A3, SLCO1B3 | DRD2 32/4885HRH1 835/4885DRD3 50/4885 |
| US-20100204469-A1 | CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF | SLC18A2, SLC6A3, SLCO1B3 | DRD2 32/4885HRH1 835/4885DRD3 50/4885 |
| US-20080108606-A1 | Conjugated psychotropic drugs and uses thereof | SLC18A2, SLC6A3, SLCO1B3 | DRD2 32/4885HRH1 835/4885DRD3 50/4885 |
| US-20070197514-A1 | Conjugated psychotropic drugs and uses thereof | SLC18A2, SLC6A3, SLCO1B3 | DRD2 32/4885HRH1 835/4885DRD3 50/4885 |
| US-20120309748-A1 | CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF | SLC18A2, SLC6A3, SLCO1B3 | DRD2 32/4885HRH1 835/4885DRD3 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.