Thiopropazate

Thiopropazate

SCHEMBL144729

CC(=O)OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.72
LMNA P02545 6/20 0.72
DRD2 P14416 6/20 0.72
CYP2D6 P10635 6/20 0.72
MAPK1 P28482 5/20 0.72
ADRA2A P08913 5/20 0.72
ADRA2B P18089 5/20 0.72
ADRA2C P18825 5/20 0.72
SLC6A2 P23975 5/20 0.72
HTR2A P28223 5/20 0.72
SLC6A4 P31645 5/20 0.72
HRH1 P35367 5/20 0.72
DRD3 P35462 5/20 0.72
HTR2B P41595 5/20 0.72
SMN1; SMN2 Q16637 5/20 0.72
TP53 P04637 5/20 0.72
HTR1A P08908 5/20 0.72
CYP1A2 P05177 5/20 0.72
NPSR1 Q6W5P4 4/20 0.72
CYP3A4 P08684 4/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Thiopropazate SCHEMBL31153316 0.99 MAPT (0.70) MAPTLMNADRD2CYP2D6MAPK1
Thiopropazate SCHEMBL955966 0.99 MAPT (0.70) MAPTLMNADRD2CYP2D6MAPK1
Thiopropazate SCHEMBL955965 0.99 MAPT (0.70) MAPTLMNADRD2CYP2D6MAPK1
Thiopropazate SCHEMBL1651297 0.98 MAPT (0.69) MAPTLMNADRD2CYP2D6MAPK1
Thiopropazate SCHEMBL5972306 0.97 DRD2 (0.77) MAPTLMNADRD2CYP2D6MAPK1
SCHEMBL13464239 0.92 CYP2D6 (0.73) MAPTLMNADRD2CYP2D6MAPK1
SCHEMBL10084511 0.90 DRD2 (0.69) MAPTLMNADRD2CYP2D6MAPK1
Thiopropazate SCHEMBL13724873 0.90 MAPT (0.71) MAPTLMNADRD2CYP2D6MAPK1
SCHEMBL1041510 0.89 DRD2 (0.68) MAPTLMNADRD2CYP2D6MAPK1
SCHEMBL10084508 0.89 DRD2 (0.67) MAPTLMNADRD2CYP2D6MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1587 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4618973-A1 METHODS OF SWITCHING NEUROPSYCHIATRIC MEDICATIONS USING ULOTARONT Sumitomo Pharma America, Inc. (US) 2025-09-24 EP claimed
US-20250179064-A1 BENZOQUINOLONE INHIBITORS OF VMAT2 AUSPEX PHARMACEUTICALS LLC 2025-06-05 US claimed
WO-2024107681-A1 METHODS OF SWITCHING NEUROPSYCHIATRIC MEDICATIONS USING ULOTARONT SUMITOMO PHARMA AMERICA, INC. (US) 2024-05-23 WO claimed
US-20240000810-A1 USE OF CANNABINOIDS IN THE TREATMENT OF TOURETTE SYNDROME AND TIC DISORDERS Orcosa Inc. (US) 2024-01-04 US claimed
US-20230321073-A1 COMPOSITIONS AND METHODS FOR TREATING METABOLIC DYSREGULATION Response IP Holding Company, LLC (US) 2023-10-12 US claimed
EP-4192579-A2 COMPOSITIONS AND METHODS FOR TREATING METABOLIC DYSREGULATION Response IP Holding Company, LLC (US) 2023-06-14 EP claimed
WO-2022032077-A2 COMPOSITIONS AND METHODS FOR TREATING METABOLIC DYSREGULATION REDUX THERAPEUTICS, LLC (US) 2022-02-10 WO claimed
EP-3770159-A1 BENZOQUINOLONE INHIBITOR OF VMAT2 Auspex Pharmaceuticals, Inc. (US) 2021-01-27 EP claimed
EP-3421469-A1 BENZOQUINOLONE INHIBITORS OF VMAT2 Auspex Pharmaceuticals, Inc. (US) 2019-01-02 EP claimed
EP-3351247-A1 BENZOQUINOLONE INHIBITORS OF VMAT2 Auspex Pharmaceutical, Inc. (US) 2018-07-25 EP claimed
US-5492907-A ADMINISTERING AN ALPHA2-ADRENERGIC RECEPTOR ANTAGONIST AND A D2 DOPAMINE RECEPTOR ANTAGONIST; TREATS SCHIZOPHRENIA THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH & HUMAN SERVICES (US) 1996-02-20 US claimed
US-5474783-A In the form of sheet; used for applying to the dermis NOVEN PHARMACEUTICALS, INC. (US) 1995-12-12 US claimed
WO-1995018603-A1 TRANSDERMAL DEVICE CONTAINING POLYVINYLPYRROLIDONE AS SOLUBILITY ENHANCER NOVEN PHARMACEUTICALS, INC. (US) 1995-07-13 WO claimed
EP-0591432-A4 SOLUBILITY PARAMETER BASED DRUG DELIVERY SYSTEM AND METHOD FOR ALTERING DRUG SATURATION CONCENTRATION. NOVEN PHARMA (US) 1995-05-17 EP claimed
EP-0591432-A1 SOLUBILITY PARAMETER BASED DRUG DELIVERY SYSTEM AND METHOD FOR ALTERING DRUG SATURATION CONCENTRATION NOVEN PHARMACEUTICALS, INC. (US) 1994-04-13 EP claimed
WO-1993000058-A1 SOLUBILITY PARAMETER BASED DRUG DELIVERY SYSTEM AND METHOD FOR ALTERING DRUG SATURATION CONCENTRATION NOVEN PHARMACEUTICALS, INC. (US) 1993-01-07 WO claimed
EP-0180364-B1 PHARMACEUTICAL COMPOSITIONS CONTAINING PHENOTHIAZINES RECKITT AND COLMAN PRODUCTS LIMITED (GB) 1990-03-07 EP claimed
EP-0174342-B1 BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES UNIVERSITY OF FLORIDA (US) 1989-12-20 EP claimed
EP-0174342-A1 BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES. UNIV FLORIDA (US) 1986-03-19 EP claimed
WO-1985003937-A1 BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES UNIVERSITY OF FLORIDA (US) 1985-09-12 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250179064-A1 BENZOQUINOLONE INHIBITORS OF VMAT2 ACAT2, CPT1A, SLC18A2 MAPT 1179/4885LMNA 1919/4885DRD2 2127/4885
US-20230321073-A1 COMPOSITIONS AND METHODS FOR TREATING METABOLIC DYSREGULATION LIPC, CPT1A, CETP MAPT 1631/4885LMNA 2305/4885DRD2 4836/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.