Isoguanine

Isoguanine

SCHEMBL134675

Nc1nc(=O)[nH]c2nc[nH]c12

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 1/20 0.53
RIN1 Q13671 1/20 0.53
ADORA3 P0DMS8 5/20 0.49
ALDH1A1 P00352 2/20 0.49
USP2 O75604 1/20 0.49
TP53 P04637 1/20 0.49
HPGD P15428 1/20 0.49
PTGS1 P23219 1/20 0.49
MAPK3 P27361 1/20 0.49
XDH P47989 1/20 0.49
HBB P68871 1/20 0.49
PAX8 Q06710 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
GDA Q9Y2T3 2/20 0.48
ACHE P22303 1/20 0.48
PNP P00491 1/20 0.44
PDPK1 O15530 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
ADORA2B P29275 5/20 0.43
ADORA2A P29274 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isoguanine SCHEMBL8591970 0.98 ABL1 (0.51) ABL1RIN1ADORA3ALDH1A1USP2
Isoguanine SCHEMBL10996058 0.92 ABL1 (0.46) ABL1RIN1ADORA3ALDH1A1USP2
Isoguanine SCHEMBL28284042 0.89 ABL1 (0.44) ABL1RIN1ADORA3ALDH1A1USP2
Isoguanine SCHEMBL7718191 0.85 ADORA3 (0.41) ABL1RIN1ADORA3ALDH1A1USP2
Isoguanine SCHEMBL5074780 0.85 ABL1 (0.41) ABL1RIN1ADORA3ALDH1A1USP2
Isoguanine SCHEMBL22660141 0.82 PI4KA (0.39) ABL1RIN1ADORA3ALDH1A1USP2
SCHEMBL23607957 0.78 ABL1 (0.46) ABL1RIN1ADORA3ALDH1A1USP2
SCHEMBL23607956 0.74 ABL1 (0.42) ABL1RIN1ADORA3ALDH1A1USP2
Guanine SCHEMBL342789 0.73 ADORA3 (0.62) ABL1RIN1ADORA3ALDH1A1USP2
SCHEMBL7487801 0.71 ABL1 (0.55) ABL1RIN1ADORA3ALDH1A1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 15547 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026106497-A2 FUNCTIONALIZED CIRCULAR RNA AND METHODS AND INTERMEDIATES FOR THEIR PRODUCTION SIEĆ BADAWCZA ŁUKASIEWICZ – PORT POLSKI OSRODEK ROZWOJU TECHNOLOGII (PL) 2026-05-21 WO claimed
CN-122029176-A Containing a plurality of oligonucleotides modified oligonucleotides 阿达尔克斯制药有限公司 2026-05-12 CN claimed
CN-122029177-A Oligonucleotides containing multiple ligands and/or lipids 阿达尔克斯制药有限公司 2026-05-12 CN claimed
CN-122028913-A Oligonucleotides containing ligands in nucleobases, 2 'or 3' positions 阿达尔克斯制药有限公司 2026-05-12 CN claimed
WO-2026090528-A2 CIRCULARLY STRUCTURED GUIDE RNAS FOR CRISPR GENOME EDITING UNIVERSITY OF MASSACHUSETTS (US) 2026-04-30 WO claimed
EP-4720304-A2 IMPROVED MODULAR PRIME EDITING WITH MODIFIED EFFECTORS AND TEMPLATES University of Massachusetts (US) 2026-04-08 EP claimed
EP-4713458-A2 COMPOSITIONS AND METHODS FOR REGULATING EXPRESSION OF ATXN2 Riboway Therapeutics, Inc. (US) 2026-03-25 EP claimed
EP-4709860-A1 COMPOSITIONS AND METHODS FOR IMPROVED GENOME EDITING WITH NME2CAS9 AND NME2-SMUCAS9 VARIANTS University of Massachusetts (US) 2026-03-18 EP claimed
EP-4703360-A1 INTERMEDIATE FOR PREPARING OLIGONUCLEOTIDE ANALOG OR SALT THEREOF, AND PREPARATION METHOD THEREFOR Shanghai Senhui Medicine Co., Ltd. (CN) 2026-03-04 EP claimed
CN-121586586-A Process for preparing ophthalmic compositions of low solubility materials 全福生物科技股份有限公司 2026-02-27 CN claimed
WO-2001094638-A2 ASYNCHRONOUS PRIMED PCR APPLERA CORPORATION (US) 2001-12-13 WO claimed
US-6316228-B1 Efficient synthesis of nucleosides THE UNIVERSITY OF IOWA RESEARCH FOUNDATION 2001-11-13 US claimed
EP-1047705-A2 NUCLEOBASE OLIGOMERS THE PERKIN-ELMER CORPORATION (US) 2000-11-02 EP claimed
US-6127539-A Cyclopentenecarboxamide derivative, method for preparing the same and bicycloamide derivative used therein KURARAY CO., LTD. (JP) 2000-10-03 US claimed
US-6054568-A Nucleobase oligomers THE PERKIN-ELMER CORPORATION (US) 2000-04-25 US claimed
EP-0931090-A1 IMPROVED CHIMERIC OLIGONUCLEOTIDE VECTORS THE PERKIN-ELMER CORPORATION (US) 1999-07-28 EP claimed
WO-1999036429-A2 NUCLEOBASE OLIGOMERS THE PERKIN-ELMER CORPORATION (US) 1999-07-22 WO claimed
US-5817812-A Cyclopentenecarboxamide derivative, method for preparing the same and bicycloamide derivative used therein KURARAY CO., LTD. (JP) 1998-10-06 US claimed
WO-1998039353-A1 IMPROVED CHIMERIC OLIGONUCLEOTIDE VECTORS THE PERKIN-ELMER CORPORATION (US) 1998-09-11 WO claimed
WO-1998017781-A1 EFFICIENT SYNTHESIS OF NUCLEOSIDES UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1998-04-30 WO claimed