Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | AOC2 | O75106 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13472168 | 0.80 | P2RX7 (0.48) | P2RX7CNR2 | |
| SCHEMBL1583253 | 0.80 | P2RX7 (0.46) | P2RX7MEN1KMT2ACNR2 | |
| SCHEMBL18702191 | 0.79 | P2RX7 (0.49) | P2RX7HRH3AOC2MAOARIPK1 | |
| SCHEMBL13223521 | 0.78 | P2RX7 (0.44) | P2RX7HRH3AOC2MAOARIPK1 | |
| SCHEMBL12788698 | 0.77 | POLB (0.47) | P2RX7KMT2APARP1PARP2PLA2G2A | |
| SCHEMBL24664731 | 0.74 | P2RX7 (0.51) | P2RX7MEN1KMT2APARP1PARP2 | |
| SCHEMBL27339801 | 0.73 | P2RX7 (0.38) | P2RX7MEN1KMT2AL3MBTL1 | |
| SCHEMBL17471596 | 0.72 | KMT2A (0.47) | HRH3MEN1KMT2AL3MBTL1 | |
| SCHEMBL1583540 | 0.72 | CNR2 (0.40) | P2RX7PLA2G2ACNR2 | |
| SCHEMBL1583254 | 0.72 | P2RX7 (0.41) | P2RX7HRH3MEN1KMT2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293757-B2 | 5-(4-(haloalkoxy)phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC (BM) | 2012-10-23 | — | — | US | disclosed |