Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27369454 | 0.89 | P2RX7 (0.49) | P2RX7ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL24664424 | 0.83 | P2RX7 (0.52) | P2RX7HPGDSMN1; SMN2PARP1PARP2 | |
| SCHEMBL1583254 | 0.80 | P2RX7 (0.41) | P2RX7MEN1KMT2AHPGDPARP1 | |
| SCHEMBL1583253 | 0.79 | P2RX7 (0.46) | P2RX7ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16475199 | 0.75 | TMEM97 (0.52) | P2RX7MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7868166 | 0.75 | LMNA (0.46) | P2RX7ALDH1A1SMN1; SMN2MAPTPARP1 | |
| SCHEMBL13472124 | 0.74 | P2RX7 (0.48) | P2RX7MEN1KMT2APARP1PARP2 | |
| SCHEMBL17624340 | 0.73 | CYP1A2 (0.42) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL18824250 | 0.72 | LMNA (0.46) | P2RX7ALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL1583540 | 0.71 | CNR2 (0.40) | P2RX7ALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059665-A1 | DIMERIC COMPOUNDS AS INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2024-03-21 | — | — | WO | disclosed |
| WO-2022198196-A1 | INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |