Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 9/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.34 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.34 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12788698 | 0.83 | POLB (0.47) | P2RX7 | |
| SCHEMBL13472124 | 0.80 | P2RX7 (0.48) | P2RX7CNR2 | |
| SCHEMBL13472169 | 0.80 | LMNA (0.44) | P2RX7LMNASMN1; SMN2CSNK1ECSNK1D | |
| SCHEMBL1583253 | 0.77 | P2RX7 (0.46) | P2RX7LMNASMN1; SMN2CNR2 | |
| SCHEMBL13472127 | 0.74 | LMNA (0.49) | LMNASMN1; SMN2CNR2GAA | |
| SCHEMBL13934439 | 0.71 | POLB (0.47) | P2RX7 | |
| SCHEMBL24664731 | 0.70 | P2RX7 (0.51) | P2RX7SMN1; SMN2 | |
| SCHEMBL27339801 | 0.69 | P2RX7 (0.38) | P2RX7 | |
| SCHEMBL26748677 | 0.69 | POLB (0.37) | P2RX7 | |
| SCHEMBL1583540 | 0.69 | CNR2 (0.40) | P2RX7LMNASMN1; SMN2CNR2TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293757-B2 | 5-(4-(haloalkoxy)phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC (BM) | 2012-10-23 | — | — | US | disclosed |