Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM1 | P23921 | 1/20 | 0.79 |
| ▸ | ESR1 | P03372 | 1/20 | 0.70 |
| ▸ | ESRRG | P62508 | 1/20 | 0.70 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.65 |
| ▸ | ECE2 | P0DPD6 | 2/20 | 0.65 |
| ▸ | ECE1 | P42892 | 2/20 | 0.65 |
| ▸ | MUS81 | Q96NY9 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | GCGR | P47871 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.59 |
| ▸ | AR | P10275 | 1/20 | 0.55 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830921 | 1.00 | RRM1 (0.79) | RRM1ESR1ESRRGESR2MEN1 | |
| SCHEMBL2830922 | 1.00 | RRM1 (0.79) | RRM1ESR1ESRRGESR2MEN1 | |
| SCHEMBL18963230 | 0.88 | RRM1 (1.00) | RRM1ESR1ESRRGESR2MEN1 | |
| SCHEMBL2836881 | 0.88 | RRM1 (0.85) | RRM1ESR1ESRRGESR2MEN1 | |
| SCHEMBL14983909 | 0.88 | DNM1 (0.82) | RRM1ESR1ESRRGESR2MEN1 | |
| SCHEMBL2836877 | 0.88 | RRM1 (0.85) | RRM1ESR1ESRRGESR2MEN1 | |
| SCHEMBL13475422 | 0.88 | RRM1 (0.85) | RRM1ESR1ESRRGESR2MEN1 | |
| SCHEMBL20115424 | 0.85 | MEN1 (0.75) | RRM1MEN1KMT2APOLBDNM1 | |
| SCHEMBL20299057 | 0.85 | MEN1 (0.75) | RRM1MEN1KMT2APOLBDNM1 | |
| SCHEMBL21292852 | 0.85 | MEN1 (0.63) | RRM1ESRRGMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029773-A1 | Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift) | LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) | 2010-02-04 | — | — | US | disclosed |
| US-20100029773-A1 | Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift) | LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) | 2010-02-04 | — | — | US | disclosed |
| EP-1751553-B1 | IDENTIFICATION OF ANTI-PRION DRUGS BY HIGH-THROUGHPUT SCREENING BASED ON SIFT | UNIV MUENCHEN L MAXIMILIANS (DE) | 2008-10-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029773-A1 | Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift) | PRNP, MAPT, HTT | RRM1 2731/4885ESR1 4699/4885ESRRG 4413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.