Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM1 | P23921 | 2/20 | 0.85 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | ESR1 | P03372 | 1/20 | 0.67 |
| ▸ | ESRRG | P62508 | 1/20 | 0.67 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.67 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.66 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.66 |
| ▸ | ECE1 | P42892 | 1/20 | 0.66 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2836881 | 1.00 | RRM1 (0.85) | RRM1NTRK1NPSR1ESR1ESRRG | |
| SCHEMBL2836877 | 1.00 | RRM1 (0.85) | RRM1NTRK1NPSR1ESR1ESRRG | |
| SCHEMBL18963230 | 0.92 | RRM1 (1.00) | RRM1NTRK1NPSR1ESR1ESRRG | |
| SCHEMBL14983909 | 0.89 | DNM1 (0.82) | RRM1NTRK1ESR1ESRRGESR2 | |
| SCHEMBL13475429 | 0.88 | RRM1 (0.79) | RRM1NTRK1NPSR1ESR1ESRRG | |
| SCHEMBL2830921 | 0.88 | RRM1 (0.79) | RRM1NTRK1NPSR1ESR1ESRRG | |
| SCHEMBL2830922 | 0.88 | RRM1 (0.79) | RRM1NTRK1NPSR1ESR1ESRRG | |
| SCHEMBL13569020 | 0.82 | ESR1 (0.89) | RRM1ESR1ESRRGESR2DNM1 | |
| SCHEMBL11782593 | 0.82 | RRM1 (0.75) | RRM1NTRK1NPSR1MAPTTP53 | |
| SCHEMBL11782587 | 0.82 | RRM1 (0.75) | RRM1NTRK1NPSR1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021225982-A1 | SOS1 ALLOSTERIC SITE TARGETING | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2021-11-11 | — | — | WO | disclosed |
| US-20210338694-A1 | SOS1 ALLOSTERIC SITE TARGETING | UNIVERSITY OF CINCINNATI | 2021-11-04 | — | — | US | disclosed |
| US-9296716-B2 | Androgen receptor ligands | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIV. TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2016-03-29 | — | — | US | disclosed |
| US-9296716-B2 | Androgen receptor ligands | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIV. TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2016-03-29 | — | — | US | disclosed |
| US-20140357682-A1 | ANDROGEN RECEPTOR LIGANDS | The Provost, Fellows, Foundation Scholars, & the Other Members of Board, of The College of the Holy (IE) | 2014-12-04 | — | — | US | disclosed |
| US-20140357682-A1 | ANDROGEN RECEPTOR LIGANDS | The Provost, Fellows, Foundation Scholars, & the Other Members of Board, of The College of the Holy (IE) | 2014-12-04 | — | — | US | disclosed |
| WO-2013076275-A1 | ANDROGEN RECEPTOR LIGANDS | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIV.TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2013-05-30 | — | — | WO | disclosed |
| US-20100029773-A1 | Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift) | LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) | 2010-02-04 | — | — | US | disclosed |
| US-20100029773-A1 | Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift) | LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) | 2010-02-04 | — | — | US | disclosed |
| EP-1751553-B1 | IDENTIFICATION OF ANTI-PRION DRUGS BY HIGH-THROUGHPUT SCREENING BASED ON SIFT | UNIV MUENCHEN L MAXIMILIANS (DE) | 2008-10-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029773-A1 | Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift) | PRNP, MAPT, HTT | RRM1 2731/4885NTRK1 558/4885NPSR1 3439/4885 |
| US-20210338694-A1 | SOS1 ALLOSTERIC SITE TARGETING | SOS1, SOS2, SOST | RRM1 2533/4885NTRK1 1223/4885NPSR1 768/4885 |
| US-20140357682-A1 | ANDROGEN RECEPTOR LIGANDS | AR, NR5A1, SHBG | RRM1 1008/4885NTRK1 244/4885NPSR1 166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.