Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 3/20 | 0.40 |
| ▸ | BACE1 | P56817 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13140601 | 0.82 | MEN1 (0.52) | MEN1KMT2AMAPTGAAATM | |
| SCHEMBL1557163 | 0.82 | MEN1 (0.48) | MEN1KMT2AMAPTGAAATM | |
| SCHEMBL6921729 | 0.82 | MEN1 (0.48) | MEN1KMT2AMAPTGAAATM | |
| SCHEMBL13140631 | 0.80 | ALDH1A1 (0.43) | MEN1KMT2AMAPTGAAATM | |
| SCHEMBL13140550 | 0.79 | MEN1 (0.46) | MEN1KMT2AMAPTGAAATM | |
| SCHEMBL1556923 | 0.77 | MAPT (0.52) | MEN1KMT2AMAPTGAAATM | |
| SCHEMBL2219482 | 0.76 | ALDH1A1 (0.58) | MEN1KMT2AMAPTGAAATM | |
| SCHEMBL4882922 | 0.76 | ALDH1A1 (0.58) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL5558132 | 0.76 | PDE10A (0.50) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL13140535 | 0.75 | MRGPRX4 (0.47) | MEN1KMT2AMAPTGAAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2149561-A1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2010-02-03 | — | — | EP | disclosed |