Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MPL | P40238 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2481128 | 0.84 | MEN1 (0.47) | MAPTALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL20987960 | 0.80 | ALDH1A1 (0.63) | MAPTALDH1A1HTTNPC1RAB9A | |
| SCHEMBL3147864 | 0.78 | ALDH1A1 (0.51) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13477405 | 0.77 | MEN1 (0.48) | MAPTALDH1A1HTTMEN1KMT2A | |
| Bromide SCHEMBL5897641 | 0.77 | ALDH1A1 (0.50) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13140638 | 0.76 | NPC1 (0.61) | MAPTALDH1A1HTTNPC1RAB9A | |
| SCHEMBL29451720 | 0.75 | PKM (0.70) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4604023 | 0.75 | PKM (0.70) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9813248 | 0.75 | MEN1 (0.44) | MAPTALDH1A1HTTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL9381859 | 0.74 | PKM (0.68) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10696707-B2 | Polyene macrolide derivative | SHIONOGI & CO., LTD. (JP) | 2020-06-30 | — | — | US | disclosed |
| US-20190135847-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2019-05-09 | — | — | US | disclosed |
| US-10246478-B2 | Polyene macrolide derivative | SHIONOGI & CO., LTD. (JP) | 2019-04-02 | — | — | US | disclosed |
| US-20170190729-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2017-07-06 | — | — | US | disclosed |
| US-20170190729-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2017-07-06 | — | — | US | disclosed |
| EP-3156410-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2017-04-19 | — | — | EP | disclosed |
| US-8614217-B2 | Fungicide hydroximoyl-tetrazole derivatives | BAYER CROPSCIENCE AG (DE) | 2013-12-24 | — | — | US | disclosed |
| US-8580799-B2 | Fungicide hydroximoyl-heterocycles derivatives | BAYER CROPSCIENCE AG (DE) | 2013-11-12 | — | — | US | disclosed |
| US-20110294829-A1 | FUNGICIDE HYDROXIMOYL-HETEROCYCLES DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2011-12-01 | — | — | US | disclosed |
| EP-2376464-A1 | FUNGICIDE HYDROXIMOYL-HETEROCYCLES DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2011-10-19 | — | — | EP | disclosed |
| US-20110201613-A1 | FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2011-08-18 | — | — | US | disclosed |
| EP-2303864-A1 | FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES | Bayer CropScience AG (DE) | 2011-04-06 | — | — | EP | disclosed |
| WO-2010066697-A1 | FUNGICIDE HYDROXIMOYL-HETEROCYCLES DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2010-06-17 | — | — | WO | disclosed |
| WO-2010000841-A1 | FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES | BAYER CROPSCIENCE SA (FR) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190729-A1 | POLYENE MACROLIDE DERIVATIVE | ERG28, RPL23, RPL10 | MAPT 2901/4885ALDH1A1 4446/4885HTT 1050/4885 |
| US-10246478-B2 | Polyene macrolide derivative | ERG28, RPL23, RPL10 | MAPT 2901/4885ALDH1A1 4446/4885HTT 1050/4885 |
| US-20190135847-A1 | POLYENE MACROLIDE DERIVATIVE | ERG28, RPL23, RPL10 | MAPT 2901/4885ALDH1A1 4446/4885HTT 1050/4885 |
| US-20110201613-A1 | FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES | HPD, HAAO, CYP8B1 | MAPT 3187/4885ALDH1A1 2708/4885HTT 222/4885 |
| US-20110294829-A1 | FUNGICIDE HYDROXIMOYL-HETEROCYCLES DERIVATIVES | HAAO, HPD, HAO1 | MAPT 3696/4885ALDH1A1 1606/4885HTT 121/4885 |
| US-10696707-B2 | Polyene macrolide derivative | ERG28, RPL23, RPL10 | MAPT 2901/4885ALDH1A1 4446/4885HTT 1050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.