Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 5/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20621075 | 0.92 | BRS3 (0.46) | BRS3TP53MDM2TDP1TAAR1 | |
| SCHEMBL20620985 | 0.91 | GALK1 (0.40) | BRS3TP53MAPTTHRBMRGPRX4 | |
| SCHEMBL13477442 | 0.88 | BRS3 (0.58) | BRS3MAPTTDP1TAAR1NPC1 | |
| SCHEMBL19085207 | 0.83 | BRS3 (0.52) | BRS3TP53MAPT | |
| SCHEMBL20620544 | 0.78 | BRS3 (0.40) | BRS3MAPTTHRB | |
| SCHEMBL20620611 | 0.78 | BRS3 (0.39) | BRS3MAPTNPC1RAB9AATM | |
| SCHEMBL19085337 | 0.78 | BRS3 (0.49) | BRS3TP53MAPTMRGPRX4NPC1 | |
| SCHEMBL19085243 | 0.77 | BRS3 (0.49) | BRS3TP53MAPTTHRBTDP1 | |
| SCHEMBL19085348 | 0.77 | MDM2 (0.43) | BRS3TP53MDM2MAPT | |
| SCHEMBL20620524 | 0.77 | BRS3 (0.44) | BRS3MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2149561-A1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2010-02-03 | — | — | EP | disclosed |