Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13478881 | 0.86 | KCNH2 (0.56) | KCNH2GPR119SIGMAR1DRD2HTR2A | |
| SCHEMBL4260839 | 0.85 | GAA (0.60) | KCNH2GPR119GAAOPRM1OPRD1 | |
| SCHEMBL13478879 | 0.85 | KCNH2 (0.58) | KCNH2GPR119GAASIGMAR1DRD2 | |
| SCHEMBL13478882 | 0.84 | KCNH2 (0.67) | KCNH2OPRM1SIGMAR1DRD2HTR2A | |
| SCHEMBL13194962 | 0.82 | KCNH2 (0.61) | KCNH2OPRM1SIGMAR1DRD2HTR2A | |
| SCHEMBL13478887 | 0.81 | CCR5 (0.57) | KCNH2GPR119SIGMAR1DRD2HTR2A | |
| SCHEMBL8230948 | 0.81 | HDAC1 (0.54) | GAAOPRM1OPRD1OPRK1KDM4E | |
| SCHEMBL4201843 | 0.80 | KCNH2 (0.48) | KCNH2GPR119GAAOPRM1OPRD1 | |
| SCHEMBL5252348 | 0.80 | KCNH2 (0.46) | KCNH2GPR119GAAOPRM1OPRD1 | |
| SCHEMBL4267387 | 0.78 | GAA (0.64) | KCNH2GAAOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2151439-A1 | NITROGENATED AROMATIC 6-MEMBERED RING DERIVATIVE, AND PHARMACEUTICAL AGENT COMPRISING THE SAME | Asubio Pharma Co., Ltd. (JP) | 2010-02-10 | — | — | EP | disclosed |