Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9269862 | 0.79 | TDP1 (0.55) | TDP1MAPK1HIF1ASLC6A2SLC6A3 | |
| SCHEMBL27773060 | 0.76 | TDP1 (0.52) | TDP1MAPK1HIF1ASLC6A2SLC6A3 | |
| SCHEMBL1713120 | 0.75 | TDP1 (0.50) | TDP1MAPK1HIF1ASLC6A2SLC6A3 | |
| SCHEMBL16290120 | 0.75 | TDP1 (0.50) | TDP1MAPK1HIF1ASLC6A2SLC6A3 | |
| SCHEMBL8496636 | 0.75 | TDP1 (0.50) | TDP1MAPK1HIF1ASLC6A2SLC6A3 | |
| SCHEMBL8448799 | 0.74 | ALDH1A1 (0.55) | TDP1MAPK1HIF1ASLC6A2SLC6A3 | |
| SCHEMBL20288884 | 0.73 | LMNA (0.54) | TDP1MAPK1HIF1ASLC6A2SLC6A3 | |
| SCHEMBL4151743 | 0.73 | TDP1 (0.49) | TDP1MAPK1HIF1ASLC6A2SLC6A3 | |
| SCHEMBL22624659 | 0.72 | LMNA (0.49) | TDP1MAPK1HIF1ASLC6A2SLC6A3 | |
| SCHEMBL18669821 | 0.72 | ALDH1A1 (0.49) | TDP1MAPK1HIF1ASLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551633-B1 | SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2021-03-31 | — | — | EP | disclosed |
| EP-3551633-B1 | SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2021-03-31 | — | — | EP | disclosed |
| US-10906915-B2 | Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2021-02-02 | — | — | US | disclosed |
| US-10906915-B2 | Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2021-02-02 | — | — | US | disclosed |
| EP-3551633-A1 | SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2019-10-16 | — | — | EP | disclosed |
| EP-3353155-A1 | PYRIDYL OR PYRAZINYL COMPOUNDS CARRYING A METHYL-BOUND ALPHA-AMINO ACID AMIDE GROUP | AbbVie Deutschland GmbH & Co. KG (DE) | 2018-08-01 | — | — | EP | disclosed |
| WO-2018108230-A1 | SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2018-06-21 | — | — | WO | disclosed |
| WO-2018108230-A1 | SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2018-06-21 | — | — | WO | disclosed |
| WO-2017050807-A1 | PYRIDYL OR PYRAZINYL COMPOUNDS CARRYING A METHYL-BOUND ALPHA-AMINO ACID AMIDE GROUP | AbbVie Deutschland GmbH & Co. KG (DE) | 2017-03-30 | — | — | WO | disclosed |
| US-7655699-B1 | Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors | EISAI INC. (US) | 2010-02-02 | — | — | US | disclosed |
| US-7655699-B1 | Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors | EISAI INC. (US) | 2010-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10906915-B2 | Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors | PDE4A, PDE4B, PDE12 | TDP1 353/4885MAPK1 2444/4885HIF1A 4044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.