Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 14/20 | 0.59 |
| ▸ | TUBB4A | P04350 | 8/20 | 0.59 |
| ▸ | TUBB | P07437 | 8/20 | 0.59 |
| ▸ | TUBA3C | P0DPH7 | 8/20 | 0.59 |
| ▸ | TUBA1B | P68363 | 8/20 | 0.59 |
| ▸ | TUBA4A | P68366 | 8/20 | 0.59 |
| ▸ | TUBB4B | P68371 | 8/20 | 0.59 |
| ▸ | TUBB3 | Q13509 | 8/20 | 0.59 |
| ▸ | TUBB2A | Q13885 | 8/20 | 0.59 |
| ▸ | TUBB8 | Q3ZCM7 | 8/20 | 0.59 |
| ▸ | TUBA3E | Q6PEY2 | 8/20 | 0.59 |
| ▸ | TUBA1A | Q71U36 | 8/20 | 0.59 |
| ▸ | TUBA1C | Q9BQE3 | 8/20 | 0.59 |
| ▸ | TUBB6 | Q9BUF5 | 8/20 | 0.59 |
| ▸ | TUBB2B | Q9BVA1 | 8/20 | 0.59 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.59 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.59 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.59 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17146088 | 0.92 | TUBB1 (0.60) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13900853 | 0.92 | TUBB1 (0.58) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13900854 | 0.90 | TUBB1 (0.56) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13479815 | 0.88 | TUBB1 (0.60) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13940880 | 0.87 | TUBB1 (0.57) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Fosbretabulin SCHEMBL22527585 | 0.87 | TUBB1 (0.58) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Fosbretabulin SCHEMBL29417596 | 0.87 | TUBB1 (0.61) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Fosbretabulin SCHEMBL321426 | 0.87 | TUBB1 (0.58) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Fosbretabulin SCHEMBL66079 | 0.87 | TUBB1 (0.61) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Fosbretabulin SCHEMBL29374788 | 0.87 | TUBB1 (0.61) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659261-B2 | Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts | BRISTOL-MYERS SQUIBB CO. (US) | 2010-02-09 | — | — | US | disclosed |
| US-7659262-B2 | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di-amino acid salts, and mono- and di-amino acid ester salts | BRISTOL-MYERS SQUIBB CO. (US) | 2010-02-09 | — | — | US | disclosed |
| US-20090264382-A1 | Methods for Treating Hematopoietic Neoplasms | CHAPLIN DAVID | 2009-10-22 | — | — | US | disclosed |
| US-20090258937-A1 | Methods for Modulating Tumor Growth and Metastasis | BRISTOL MYERS SQUIBB COMPANY | 2009-10-15 | — | — | US | disclosed |
| US-20090186857-A1 | Combretastatin A-4 Phosphate Prodrug Mono- and Di- Organic Amine Salts, Mono- and Di- Amino Acid Salts, and Mono- and Di- Amino Acid Ester Salts | BRISTOL-MYERS SQUIBB COMPANY | 2009-07-23 | — | — | US | disclosed |
| US-7557096-B2 | Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof | Arizona Board of Regents, a body corporate of the State of Arizona, acting for an on behalf of the Arizona State University (US) | 2009-07-07 | — | — | US | disclosed |
| US-7524832-B2 | Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts and mono-and di-amino acid ester salts | BRISTOL-MYERS SQUIBB CO. (US) | 2009-04-28 | — | — | US | disclosed |
| US-20080146528-A1 | SYNTHESIS OF COMBRETASTATIN A-4 PRODRUGS AND TRANS-ISOMERS THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-06-19 | — | — | US | disclosed |
| US-20070270617-A1 | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di-amino acid salts, and mono- and di-amino acid ester salts | BRISTOL-MYERS SQUIBB COMPANY | 2007-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146528-A1 | SYNTHESIS OF COMBRETASTATIN A-4 PRODRUGS AND TRANS-ISOMERS THEREOF | COASY, TMPRSS4, CDK4 | TUBB1 2109/4885TUBB4A 532/4885TUBB 2244/4885 |
| US-20090264382-A1 | Methods for Treating Hematopoietic Neoplasms | MCL1, CA4, ASAH2 | TUBB1 612/4885TUBB4A 90/4885TUBB 705/4885 |
| US-20090258937-A1 | Methods for Modulating Tumor Growth and Metastasis | HGF, HDGF, MKI67 | TUBB1 46/4885TUBB4A 74/4885TUBB 106/4885 |
| US-20070270617-A1 | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di-amino acid salts, and mono- and di-amino acid ester salts | SLC7A1, CAD, GART | TUBB1 2278/4885TUBB4A 385/4885TUBB 1601/4885 |
| US-20090186857-A1 | Combretastatin A-4 Phosphate Prodrug Mono- and Di- Organic Amine Salts, Mono- and Di- Amino Acid Salts, and Mono- and Di- Amino Acid Ester Salts | SLC7A1, CAD, GART | TUBB1 2278/4885TUBB4A 385/4885TUBB 1601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.