Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | EDNRA | P25101 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | SCN1A | P35498 | 2/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.49 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.49 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1349837 | 0.88 | MEN1 (0.54) | MEN1KMT2APOLBSCN9AALDH1A1 | |
| SCHEMBL1349031 | 0.79 | ALDH1A1 (0.53) | MEN1KMT2ASCN9AALDH1A1LMNA | |
| SCHEMBL326633 | 0.76 | ALDH1A1 (0.71) | MEN1KMT2ASCN9AALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL27575105 | 0.75 | ALDH1A1 (0.69) | MEN1KMT2ASCN9AALDH1A1LMNA | |
| SCHEMBL1350247 | 0.74 | SCN8A (0.53) | SCN9AALDH1A1LMNAKDM4ETDP1 | |
| SCHEMBL3070565 | 0.74 | ALDH1A1 (0.68) | MEN1KMT2APOLBSCN9AALDH1A1 | |
| SCHEMBL8388562 | 0.73 | PPIA (0.76) | MEN1KMT2APOLBALDH1A1LMNA | |
| SCHEMBL714065 | 0.72 | MEN1 (0.64) | MEN1KMT2APOLBSCN9AALDH1A1 | |
| SCHEMBL31305589 | 0.71 | NPY5R (0.68) | MEN1KMT2APOLBALDH1A1KDM4E | |
| SCHEMBL724250 | 0.71 | NPY5R (0.72) | MEN1KMT2APOLBALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063080-B2 | Inhibitors of ion channels | ICAGEN, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-20100041707-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2010-02-18 | — | — | US | disclosed |
| US-7615569-B2 | Inhibitors of ion channels | ICAGEN, INC. (US) | 2009-11-10 | — | — | US | disclosed |
| EP-1922068-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | Icagen, Inc. (US) | 2008-05-21 | — | — | EP | disclosed |
| US-20070078145-A1 | INHIBITORS OF ION CHANNELS | ICAGEN (US) | 2007-04-05 | — | — | US | disclosed |
| WO-2007021941-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | ICAGEN, INC. (US) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041707-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPA1, CACNA1B | MEN1 4662/4885KMT2A 1628/4885POLB 4434/4885 |
| US-20070078145-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPA1, CACNA1B | MEN1 4662/4885KMT2A 1628/4885POLB 4434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.