Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | EDNRA | P25101 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1349837 | 0.82 | MEN1 (0.54) | ALDH1A1LMNAKDM4ETDP1CYP2C9 | |
| SCHEMBL1348233 | 0.79 | MEN1 (0.53) | ALDH1A1LMNAKDM4ETDP1CYP2C9 | |
| SCHEMBL326633 | 0.76 | ALDH1A1 (0.71) | ALDH1A1LMNAKDM4ETDP1CYP2C9 | |
| SCHEMBL3918863 | 0.75 | MAPT (0.75) | ALDH1A1LMNAKDM4ESMN1; SMN2MMP2 | |
| SCHEMBL3917085 | 0.75 | CHEK2 (0.67) | ALDH1A1LMNAKDM4ESMN1; SMN2MMP2 | |
| SCHEMBL9974092 | 0.75 | PKM (0.64) | ALDH1A1LMNAKDM4ETDP1SMN1; SMN2 | |
| SCHEMBL9972189 | 0.75 | PKM (0.68) | ALDH1A1LMNAKDM4ETDP1SMN1; SMN2 | |
| SCHEMBL5635439 | 0.74 | CHEK2 (0.72) | ALDH1A1LMNAKDM4ESMN1; SMN2MMP2 | |
| Hydrochloric Acid SCHEMBL27575105 | 0.74 | ALDH1A1 (0.69) | ALDH1A1LMNAKDM4ETDP1CYP2C9 | |
| SCHEMBL3564516 | 0.74 | CHEK2 (0.71) | ALDH1A1LMNAKDM4ETDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063080-B2 | Inhibitors of ion channels | ICAGEN, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-20100041707-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2010-02-18 | — | — | US | disclosed |
| US-7615569-B2 | Inhibitors of ion channels | ICAGEN, INC. (US) | 2009-11-10 | — | — | US | disclosed |
| EP-1922068-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | Icagen, Inc. (US) | 2008-05-21 | — | — | EP | disclosed |
| US-20070078145-A1 | INHIBITORS OF ION CHANNELS | ICAGEN (US) | 2007-04-05 | — | — | US | disclosed |
| WO-2007021941-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | ICAGEN, INC. (US) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041707-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPA1, CACNA1B | ALDH1A1 3009/4885LMNA 3621/4885KDM4E 2022/4885 |
| US-20070078145-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPA1, CACNA1B | ALDH1A1 3009/4885LMNA 3621/4885KDM4E 2022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.