Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 13/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.42 |
| ▸ | NAAA | Q02083 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13484267 | 0.82 | GRIA4 (0.43) | GRIA4GRIA2NAAALMNAALDH1A1 | |
| SCHEMBL13484260 | 0.82 | GRIA4 (0.38) | GRIA4GRIA2KCNH2 | |
| SCHEMBL13484266 | 0.79 | GRIA4 (0.48) | GRIA4GRIA2NAAAKCNH2 | |
| SCHEMBL13484584 | 0.79 | GRIA2 (0.57) | GRIA4GRIA2GRIA1GRIA3KCNH2 | |
| SCHEMBL13484269 | 0.78 | GRIA4 (0.43) | GRIA4GRIA2NAAALMNAALDH1A1 | |
| SCHEMBL13484255 | 0.78 | GRIA2 (0.58) | GRIA4GRIA2KCNH2 | |
| SCHEMBL13484273 | 0.77 | GRIA2 (0.39) | GRIA4GRIA2KCNH2 | |
| SCHEMBL13484285 | 0.76 | GRIA2 (0.36) | GRIA4GRIA2KCNH2 | |
| SCHEMBL13484298 | 0.76 | GRIA2 (0.44) | GRIA4GRIA2KCNH2 | |
| SCHEMBL13484592 | 0.71 | GRIA4 (0.43) | GRIA4GRIA2NAAAASAH1GRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035865-A1 | Sulfonamides and Pharmaceutical Compositions Thereof | PFIZER INC | 2010-02-11 | — | — | US | disclosed |
| US-20100035865-A1 | Sulfonamides and Pharmaceutical Compositions Thereof | PFIZER INC | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035865-A1 | Sulfonamides and Pharmaceutical Compositions Thereof | STS, SULT2A1, SULT1A1 | GRIA4 3473/4885GRIA2 3748/4885NAAA 215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.