Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 15/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13484275 | 0.83 | GRIA2 (0.39) | GRIA2KCNH2CRBNGRIA4 | |
| SCHEMBL13484584 | 0.81 | GRIA2 (0.57) | GRIA2KCNH2GRIA4 | |
| SCHEMBL13484285 | 0.80 | GRIA2 (0.36) | GRIA2KCNH2GRIA4 | |
| SCHEMBL13484272 | 0.80 | GRIA2 (0.43) | GRIA2KCNH2CRBNMKNK1MKNK2 | |
| SCHEMBL13484260 | 0.80 | GRIA4 (0.38) | GRIA2KCNH2GRIA4 | |
| SCHEMBL13484255 | 0.80 | GRIA2 (0.58) | GRIA2KCNH2GRIA4 | |
| SCHEMBL13484268 | 0.77 | GRIA4 (0.43) | GRIA2KCNH2GRIA4 | |
| SCHEMBL13484271 | 0.76 | GRIA4 (0.45) | GRIA2KCNH2GRIA4 | |
| SCHEMBL13484298 | 0.76 | GRIA2 (0.44) | GRIA2KCNH2GRIA4 | |
| SCHEMBL4606570 | 0.75 | GRIA4 (0.64) | GRIA2KCNH2GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035865-A1 | Sulfonamides and Pharmaceutical Compositions Thereof | PFIZER INC | 2010-02-11 | — | — | US | disclosed |
| US-20100035865-A1 | Sulfonamides and Pharmaceutical Compositions Thereof | PFIZER INC | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035865-A1 | Sulfonamides and Pharmaceutical Compositions Thereof | STS, SULT2A1, SULT1A1 | GRIA2 3748/4885KCNH2 1167/4885CRBN 2027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.