Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL844118 | 1.00 | CTSS (0.48) | CTSSCTSKSMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL844117 | 1.00 | CTSS (0.48) | CTSSCTSKSMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL20592740 | 0.86 | CTSK (0.51) | CTSSCTSKSMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL20592743 | 0.86 | CTSK (0.51) | CTSSCTSKSMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL3377047 | 0.86 | CTSS (0.53) | CTSSCTSKITGB3ITGA2BS1PR3 | |
| SCHEMBL3377050 | 0.86 | CTSS (0.53) | CTSSCTSKITGB3ITGA2BS1PR3 | |
| SCHEMBL4689223 | 0.85 | CTSS (0.44) | CTSSCTSKSMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL4683195 | 0.85 | CTSS (0.50) | CTSSCTSKSMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL4684444 | 0.85 | CTSS (0.50) | CTSSCTSKITGB3ITGA2BHDAC8 | |
| SCHEMBL4684445 | 0.85 | CTSS (0.50) | CTSSCTSKITGB3ITGA2BHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063085-B2 | Substituted hydantoins | HOFFMANN-LA ROCHE INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-20090170920-A1 | SUBSTITUTED HYDANTOINS | CHEN SHAOQING | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170920-A1 | SUBSTITUTED HYDANTOINS | HNMT, HRH3, BRAF | CTSS 1187/4885CTSK 1484/4885SMN1; SMN2 2176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.