Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.36 |
| ▸ | PSD | A5PKW4 | 3/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1349065 | 0.94 | PTGDR2 (0.36) | PTGDR2PSDKDM1AMAOAPIK3CD | |
| SCHEMBL1349026 | 0.92 | PLAT (0.33) | PTGDR2PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL1349423 | 0.86 | PLAT (0.33) | PTGDR2PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL1346123 | 0.85 | KIF18A (0.38) | PTGDR2PSDCA12CA9 | |
| SCHEMBL2828897 | 0.85 | PTGDR2 (0.36) | PTGDR2PSDCSNK2A1 | |
| SCHEMBL1348707 | 0.83 | PSD (0.36) | PTGDR2PSDCSNK2A1CA12CA9 | |
| SCHEMBL1347485 | 0.80 | HPGD (0.41) | — | |
| SCHEMBL1348434 | 0.80 | HPGD (0.38) | — | |
| SCHEMBL1348328 | 0.79 | PTGDR2 (0.35) | PTGDR2PSDCSNK2A1 | |
| SCHEMBL1348311 | 0.79 | LMNA (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4801724-B2 | — | — | 2011-10-26 | — | — | JP | claimed |
| EP-1863818-B1 | ACETYLENYL-PYRAZOLO-PVRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-03-10 | — | — | EP | claimed |
| US-8063048-B2 | Acetylenyl-pyrazolo-pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-11-22 | — | — | US | disclosed |