Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | USP5 | P45974 | 1/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.63 |
| ▸ | ACLY | P53396 | 1/20 | 0.59 |
| ▸ | FPR2 | P25090 | 1/20 | 0.59 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3222471 | 0.90 | MEN1 (0.69) | SMN1; SMN2MAPTUSP5HTR2CFPR2 | |
| SCHEMBL12660313 | 0.86 | MEN1 (0.65) | SMN1; SMN2MAPTUSP5HTR2CACLY | |
| SCHEMBL15549452 | 0.83 | HTR2C (0.57) | SMN1; SMN2MAPTUSP5HTR2CACLY | |
| SCHEMBL3219839 | 0.82 | MAPT (0.66) | SMN1; SMN2MAPTUSP5HTR2CFPR2 | |
| SCHEMBL9818371 | 0.79 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL3202101 | 0.79 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTUSP5HTR2CACLY | |
| SCHEMBL6886973 | 0.78 | GAA (0.52) | SMN1; SMN2MAPTTP53ALDH1A1LMNA | |
| SCHEMBL14095894 | 0.77 | MAPT (0.63) | SMN1; SMN2MAPTUSP5HTR2CTP53 | |
| SCHEMBL3219665 | 0.77 | MAPT (0.89) | SMN1; SMN2MAPTFPR2PROKR1ALDH1A1 | |
| SCHEMBL3830424 | 0.76 | POLB (0.80) | SMN1; SMN2ALDH1A1LMNAGAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | SMN1; SMN2 3575/4885MAPT 3352/4885USP5 495/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | SMN1; SMN2 3686/4885MAPT 3097/4885USP5 505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.