Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.48 |
| ▸ | RBP4 | P02753 | 2/20 | 0.47 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14018578 | 0.83 | EPHX2 (0.59) | TRPV1EPHX2GAAHRH3HSD11B1 | |
| SCHEMBL3216080 | 0.79 | TRPV1 (0.69) | TRPV1EPHX2GAAHRH3HSD11B1 | |
| SCHEMBL30582915 | 0.79 | EPHX2 (0.68) | TRPV1EPHX2GAAHRH3HSD11B1 | |
| SCHEMBL13202913 | 0.79 | TRPV1 (0.58) | TRPV1EPHX2GAAHRH3HSD11B1 | |
| SCHEMBL3932323 | 0.78 | TRPV1 (0.62) | TRPV1EPHX2GAAHRH3HSD11B1 | |
| SCHEMBL12124657 | 0.76 | ALDH1A1 (0.59) | HSD11B1 | |
| SCHEMBL1349136 | 0.76 | EPHX2 (0.64) | TRPV1EPHX2GAAHRH3HSD11B1 | |
| SCHEMBL13489675 | 0.76 | TRPV1 (0.62) | TRPV1EPHX2GAAHRH3HSD11B1 | |
| SCHEMBL1252470 | 0.74 | TRPV1 (0.66) | TRPV1EPHX2GAAHRH3HSD11B1 | |
| SCHEMBL1351446 | 0.74 | TRPV1 (0.55) | TRPV1EPHX2GAAHRH3HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | TRPV1 4793/4885EPHX2 867/4885GAA 2353/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | TRPV1 4707/4885EPHX2 713/4885GAA 2688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.