Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 9/20 | 0.63 |
| ▸ | MKNK2 | Q9HBH9 | 9/20 | 0.63 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.62 |
| ▸ | WNT3A | P56704 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2385420 | 0.85 | LMNA (0.67) | MKNK1MKNK2CYP2A6WNT3AHTT | |
| Pyridine SCHEMBL4161687 | 0.85 | LMNA (0.56) | HTTLMNACA2ALDH1A1 | |
| SCHEMBL31338446 | 0.85 | LMNA (0.67) | MKNK1MKNK2CYP2A6WNT3AHTT | |
| SCHEMBL2334559 | 0.84 | MKNK1 (0.56) | MKNK1MKNK2CYP2A6WNT3AHTT | |
| SCHEMBL5176875 | 0.84 | EPHX2 (0.55) | MKNK1MKNK2CYP2A6ALDH1A1CYP1A2 | |
| SCHEMBL28303354 | 0.83 | MKNK1 (0.62) | MKNK1MKNK2CYP2A6WNT3AHTT | |
| SCHEMBL6027 | 0.83 | MKNK1 (0.58) | MKNK1MKNK2CYP2A6CA2CA12 | |
| SCHEMBL19376938 | 0.81 | MKNK1 (0.55) | MKNK1MKNK2CYP2A6CA2ALDH1A1 | |
| SCHEMBL12251218 | 0.81 | MKNK1 (0.58) | MKNK1MKNK2CYP2A6WNT3AHTT | |
| SCHEMBL794394 | 0.80 | NAPRT (0.69) | CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106061974-B | Maleimide derivatives as the conditioning agent of WNT approach | 新加坡科技研究局 | 2018-04-20 | — | — | CN | disclosed |
| CN-106061974-A | Maleimide derivatives as modulators of WNT pathway | 新加坡科技研究局 | 2016-10-26 | — | — | CN | disclosed |
| CN-102271678-A | 2-acylaminopropanol type glucosylceramide synthase inhibitors | — | 2011-12-07 | — | — | CN | disclosed |
| CN-101888840-A | method of treating polycystic kidney disease using brain amide derivatives | GENZYME CORP | 2010-11-17 | — | — | CN | disclosed |
| WO-2010014554-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORPORATION (US) | 2010-02-04 | — | — | WO | disclosed |