Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 11/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 11/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.55 |
| ▸ | WNT3A | P56704 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13492969 | 0.84 | MKNK1 (0.63) | MKNK1MKNK2CYP2A6WNT3AHTT | |
| SCHEMBL1124410 | 0.83 | WNT3A (0.40) | MKNK1MKNK2WNT3AHTTLMNA | |
| SCHEMBL2334696 | 0.83 | CYP17A1 (0.50) | MKNK2WNT3AHTTLMNAMAP4K4 | |
| SCHEMBL29864463 | 0.83 | NAPRT (0.61) | CYP1A2CYP3A4 | |
| SCHEMBL6664798 | 0.83 | NAPRT (0.61) | CYP1A2CYP3A4 | |
| SCHEMBL28305277 | 0.80 | MKNK1 (0.71) | MKNK1MKNK2CYP2A6LMNACA12 | |
| SCHEMBL31338446 | 0.80 | LMNA (0.67) | MKNK1MKNK2CYP2A6WNT3AHTT | |
| SCHEMBL2385420 | 0.80 | LMNA (0.67) | MKNK1MKNK2CYP2A6WNT3AHTT | |
| SCHEMBL28303354 | 0.78 | MKNK1 (0.62) | MKNK1MKNK2CYP2A6WNT3AHTT | |
| SCHEMBL1124235 | 0.78 | CA12 (0.46) | WNT3AHTTCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358673-A1 | NOVEL BIS-AMIDES AS ANTIMALARIAL AGENTS | Actelion Pharmaceuticals Ltd. (CH) | 2011-08-24 | — | — | EP | claimed |
| WO-2010058353-A1 | NOVEL BIS-AMIDES AS ANTIMALARIAL AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-05-27 | — | — | WO | claimed |
| EP-2358673-A1 | NOVEL BIS-AMIDES AS ANTIMALARIAL AGENTS | Actelion Pharmaceuticals Ltd. (CH) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010058353-A1 | NOVEL BIS-AMIDES AS ANTIMALARIAL AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-05-27 | — | — | WO | disclosed |