Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.58 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL934607 | 0.85 | EPHX2 (0.51) | MKNK1MKNK2CYP2A6KMT2ATBXAS1 | |
| SCHEMBL13492969 | 0.83 | MKNK1 (0.63) | MKNK1MKNK2CYP2A6CA12CA1 | |
| SCHEMBL933853 | 0.82 | TBXAS1 (0.68) | CYP2A6KMT2ATBXAS1 | |
| SCHEMBL933900 | 0.82 | CYP17A1 (0.51) | TBXAS1 | |
| SCHEMBL11262500 | 0.82 | FFAR1 (0.63) | — | |
| SCHEMBL2386306 | 0.81 | FFAR1 (0.69) | MKNK1MKNK2CYP2A6TBXAS1 | |
| SCHEMBL5218911 | 0.81 | TBXAS1 (0.55) | MKNK1MKNK2TBXAS1 | |
| SCHEMBL29411532 | 0.81 | HDAC3 (0.60) | KMT2A | |
| SCHEMBL21045563 | 0.81 | HDAC3 (0.60) | KMT2A | |
| SCHEMBL4966893 | 0.81 | CYP2A6 (0.69) | MKNK1MKNK2CYP2A6CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140364398-A1 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents | PFIZER INC. (US) | 2014-12-11 | — | — | US | disclosed |
| US-8853258-B2 | C-linked hydroxamic acid derivatives useful as antibacterial agents | PFIZER INC. (US) | 2014-10-07 | — | — | US | disclosed |
| EP-2488489-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | Pfizer Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| US-20120202777-A1 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents | BROWN MATTHEW FRANK (US) | 2012-08-09 | — | — | US | disclosed |
| WO-2011045703-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 2011-04-21 | — | — | WO | disclosed |
| WO-2011006935-A2 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202777-A1 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents | HAX1, LPXN, AGXT | MKNK1 3973/4885MKNK2 3792/4885CYP2A6 3223/4885 |
| US-20140364398-A1 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents | LCT, AGXT, PRXL2A | MKNK1 2060/4885MKNK2 2083/4885CYP2A6 2986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.