Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ACLY | P53396 | 1/20 | 0.52 |
| ▸ | CPT2 | P23786 | 1/20 | 0.52 |
| ▸ | CPT1A | P50416 | 1/20 | 0.52 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13495471 | 0.88 | GPR119 (0.60) | GPR119MEN1KMT2ATP53MAPT | |
| SCHEMBL3577040 | 0.88 | MAPT (0.57) | GPR119MEN1KMT2ATP53MAPT | |
| SCHEMBL2898573 | 0.88 | CPT1A (0.62) | GPR119TP53MAPTSMN1; SMN2ACLY | |
| SCHEMBL13495472 | 0.87 | GPR119 (0.54) | GPR119MEN1KMT2ATP53MAPT | |
| SCHEMBL6357903 | 0.86 | MAPT (0.63) | GPR119MEN1KMT2ATP53MAPT | |
| SCHEMBL2901001 | 0.85 | CPT1A (0.61) | GPR119MEN1KMT2ATP53MAPT | |
| SCHEMBL3236823 | 0.84 | MAPT (0.59) | GPR119MEN1KMT2ATP53MAPT | |
| SCHEMBL2904385 | 0.84 | CPT1A (0.73) | CPT2CPT1ACPT1B | |
| SCHEMBL31396031 | 0.81 | NLRP3 (0.61) | MEN1KMT2ATP53MAPTSMN1; SMN2 | |
| SCHEMBL3099054 | 0.80 | ACLY (0.56) | GPR119TP53MAPTCYP2C9ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010017827-A1 | 6-SUBSTITUTED 1-SULFONYL-2, 3-DIHYDRO-INDOLE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2010-02-18 | — | — | WO | disclosed |