Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 11/20 | 0.41 |
| ▸ | CDK4 | P11802 | 4/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.37 |
| ▸ | CCND1 | P24385 | 2/20 | 0.37 |
| ▸ | CCND3 | P30281 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CCNH | P51946 | 1/20 | 0.36 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | DKK1 | O94907 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633494 | 0.79 | PIM1 (0.54) | IKBKBPIM1PIM2CA1CA2 | |
| SCHEMBL1633110 | 0.78 | IKBKB (0.47) | IKBKBCDK4CDK6CCND1CCND3 | |
| SCHEMBL1632840 | 0.77 | IKBKB (0.48) | IKBKBCDK4CDK6CCND1CCND3 | |
| SCHEMBL1633082 | 0.74 | IKBKB (0.45) | IKBKBCDK4CDK6CCND1CCND3 | |
| SCHEMBL1474734 | 0.66 | AURKA (0.52) | IKBKBCDK4CDK6CCNA2CDK2 | |
| SCHEMBL1634935 | 0.64 | STK17A (0.50) | CDK4CDK6CCND1CCND3GSK3B | |
| SCHEMBL13498354 | 0.64 | MAPK10 (0.49) | IKBKBCDK4CCND1CCNA2CDK2 | |
| SCHEMBL12495785 | 0.62 | PARP10 (0.47) | GSK3B | |
| SCHEMBL12077346 | 0.61 | MAPK1 (0.51) | — | |
| SCHEMBL13498245 | 0.61 | CDK2 (0.48) | IKBKBCDK4CCND1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048561-A1 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048561-A1 | QUINAZOLINES FOR PDK1 INHIBITION | PDK1, PDK2, PDK3 | IKBKB 980/4885CDK4 24/4885CDK6 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.