⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14170744 | 0.76 | — | — | |
| SCHEMBL9962273 | 0.75 | POLB (0.32) | — | |
| SCHEMBL19770241 | 0.72 | DPP4 (0.32) | — | |
| SCHEMBL13434939 | 0.70 | DPP4 (0.31) | — | |
| SCHEMBL10553723 | 0.69 | NOS3 (0.32) | — | |
| SCHEMBL13502695 | 0.68 | PIK3CD (0.33) | — | |
| SCHEMBL19449153 | 0.67 | POLB (0.32) | — | |
| SCHEMBL10129310 | 0.62 | INMT (0.36) | — | |
| SCHEMBL14170734 | 0.62 | CNR1 (0.31) | — | |
| SCHEMBL17414488 | 0.60 | LMNA (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100041639-A1 | CYCLIC MALONAMIDES AS INHIBITORS OF A BETA PROTEIN PRODUCTION | BRISTOL-MYERS SQIBB PHARMA COMAPNY (US) | 2010-02-18 | — | — | US | disclosed |
| US-20090062256-A1 | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2009-03-05 | — | — | US | disclosed |