Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | QPCT | Q16769 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1887021 | 0.80 | MAPT (0.67) | MAPTKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL13503156 | 0.80 | ALDH1A1 (0.62) | MAPTKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL3970414 | 0.79 | SMN1; SMN2 (0.68) | MAPTKMT2AKDM4EALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL10448976 | 0.78 | SMN1; SMN2 (0.66) | MAPTKMT2AKDM4EALDH1A1LMNA | |
| Alcohol SCHEMBL28865932 | 0.78 | ALDH1A1 (0.59) | MAPTKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL28145455 | 0.76 | ALDH1A1 (0.61) | MAPTKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL10401274 | 0.75 | KMT2A (0.59) | MAPTKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL11771940 | 0.74 | QPCT (0.62) | MAPTKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL7413254 | 0.74 | KMT2A (0.59) | MAPTKMT2AKDM4EALDH1A1TP53 | |
| SCHEMBL85717 | 0.74 | QPCT (0.73) | MAPTKMT2AKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655684-B2 | 1-(Urea-, thiourea- and cyanoguanidine-methylene)benzyl)imidaoles, treatment of neuronal disorders, especially Alzheimer's disease, Down Syndrome, Parkinson's disease and Huntington's disease | PROBIODRUG AG (DE) | 2010-02-02 | — | — | US | disclosed |
| US-7655684-B2 | 1-(Urea-, thiourea- and cyanoguanidine-methylene)benzyl)imidaoles, treatment of neuronal disorders, especially Alzheimer's disease, Down Syndrome, Parkinson's disease and Huntington's disease | PROBIODRUG AG (DE) | 2010-02-02 | — | — | US | disclosed |
| US-20080153892-A1 | Inhibitors of Glutaminyl Cyclase | PROBIODRUG AG (DE) | 2008-06-26 | — | — | US | disclosed |
| US-20080153892-A1 | Inhibitors of Glutaminyl Cyclase | PROBIODRUG AG (DE) | 2008-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153892-A1 | Inhibitors of Glutaminyl Cyclase | GLS2, GLS, GLUL | MAPT 75/4885KMT2A 521/4885KDM4E 982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.