Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 7/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18474589 | 0.88 | NOS3 (0.43) | NOS3NOS2MAP4K4FYNMTOR | |
| SCHEMBL17555593 | 0.88 | PIK3CD (0.40) | NOS3NOS2MAP4K4EPHB4KDR | |
| SCHEMBL17555617 | 0.84 | FYN (0.44) | NOS3NOS2FYN | |
| SCHEMBL17555726 | 0.84 | FYN (0.49) | MAP4K4FYNMTOR | |
| SCHEMBL17555671 | 0.82 | CDK2 (0.43) | NOS3NOS2MAP4K4KDR | |
| SCHEMBL17555709 | 0.78 | ADORA2A (0.41) | — | |
| SCHEMBL2781920 | 0.78 | NOS3 (0.47) | NOS3NOS2EPHB4NISCH | |
| SCHEMBL18474498 | 0.77 | NOS1 (0.46) | NOS3NOS2MAP4K4CYP17A1 | |
| SCHEMBL17555701 | 0.77 | MAP4K4 (0.48) | NOS2MAP4K4 | |
| SCHEMBL17555729 | 0.76 | WNT1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012146667-A1 | IMIDAZOPYRIDINE DERIVATIVES AS PI3K INHIBITORS | ALMIRALL, S.A. (ES) | 2012-11-01 | — | — | WO | disclosed |
| EP-2518071-A1 | Imidazopyridine derivatives as PI3K inhibitors | Almirall, S.A. (ES) | 2012-10-31 | — | — | EP | disclosed |