Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | MLYCD | O95822 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16556594 | 0.84 | KDM4E (0.63) | SMN1; SMN2EPHX2NR1H4ALDH1A1KMT2A | |
| SCHEMBL10997512 | 0.82 | SMN1; SMN2 (0.67) | SMN1; SMN2EPHX2NR1H4ALDH1A1KMT2A | |
| SCHEMBL748841 | 0.80 | SMN1; SMN2 (0.64) | SMN1; SMN2EPHX2NR1H4ALDH1A1KMT2A | |
| SCHEMBL751285 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2EPHX2NR1H4ALDH1A1KMT2A | |
| SCHEMBL10642818 | 0.78 | HDAC3 (0.59) | SMN1; SMN2ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL13508328 | 0.78 | CYP1A2 (0.58) | SMN1; SMN2ALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL10642513 | 0.77 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL12203826 | 0.77 | NAAA (0.63) | SMN1; SMN2EPHX2MLYCD | |
| SCHEMBL11949250 | 0.77 | SMN1; SMN2 (0.61) | SMN1; SMN2EPHX2NR1H4ALDH1A1KMT2A | |
| SCHEMBL10645255 | 0.77 | SMN1; SMN2 (0.61) | SMN1; SMN2EPHX2NR1H4ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9101628-B2 | Methods and composition of treating a flaviviridae family viral infection | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2015-08-11 | — | — | US | disclosed |
| US-8975247-B2 | Methods and compositions of treating a flaviviridae family viral infection | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNION UNIVERSITY (US) | 2015-03-10 | — | — | US | disclosed |
| US-20120276050-A1 | METHODS AND COMPOSITIONS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-11-01 | — | — | US | disclosed |
| US-20100028299-A1 | Methods and compositions of treating a flaviviridae family viral infection | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120276050-A1 | METHODS AND COMPOSITIONS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION | NSUN3, RNGTT, NSUN2 | SMN1; SMN2 3111/4885EPHX2 3282/4885NR1H4 940/4885 |
| US-20100028299-A1 | Methods and compositions of treating a flaviviridae family viral infection | EIF2AK2, NSUN3, NSUN2 | SMN1; SMN2 2247/4885EPHX2 3267/4885NR1H4 528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.