Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.48 |
| ▸ | PRKDC | P78527 | 6/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 5/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.42 |
| ▸ | ABL1 | P00519 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17280145 | 0.84 | CASP1 (0.42) | ADORA1PIK3CDPRKDCPIK3CAPIK3CB | |
| SCHEMBL13243234 | 0.84 | KMT2A (0.47) | ADORA1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL8214222 | 0.83 | ADORA2A (0.53) | ADORA2AADORA1PIK3CDPRKDCMAPK8 | |
| SCHEMBL13509081 | 0.82 | ADORA2A (0.49) | ADORA2AADORA1PIK3CDPRKDCMAPK8 | |
| SCHEMBL13510688 | 0.78 | LTA4H (0.47) | KDM4EALDH1A1ATMTDP1L3MBTL1 | |
| SCHEMBL13510724 | 0.78 | KDM4E (0.57) | ADORA2AADORA1KDM4EMEN1KMT2A | |
| SCHEMBL14294733 | 0.77 | NR1H2 (0.54) | ADORA2AADORA1KDM4EMEN1KMT2A | |
| SCHEMBL13510682 | 0.74 | MAPK14 (0.43) | ADORA2AADORA1KDM4EMEN1KMT2A | |
| SCHEMBL10072206 | 0.73 | PTGS2 (0.40) | ADORA1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL28079530 | 0.73 | ADORA2A (0.62) | ADORA2AADORA1MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662779-B2 | Triazolyl macrocyclic hepatitis C serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2010-02-16 | — | — | US | disclosed |
| US-20090047248-A1 | TRIAZOLYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090047248-A1 | TRIAZOLYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | SPINT2, PRSS1, CTSC | ADORA2A 3161/4885ADORA1 3564/4885PIK3CD 1610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.