Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1430546 | 0.89 | LMNA (0.69) | LMNAL3MBTL1KMT2ATDP1CYP3A4 | |
| SCHEMBL1430495 | 0.86 | L3MBTL1 (0.57) | LMNAL3MBTL1KMT2ATDP1CYP3A4 | |
| SCHEMBL1429626 | 0.86 | PRKAB2 (0.54) | LMNAL3MBTL1KMT2ATDP1CYP3A4 | |
| SCHEMBL2835516 | 0.83 | KMT2A (0.56) | LMNAL3MBTL1KMT2ATDP1CYP3A4 | |
| SCHEMBL1429882 | 0.83 | KMT2A (0.56) | LMNAL3MBTL1KMT2ATDP1CYP3A4 | |
| SCHEMBL13512952 | 0.82 | KMT2A (0.42) | LMNAKMT2AMEN1 | |
| SCHEMBL1429810 | 0.80 | MEN1 (0.52) | LMNAL3MBTL1KMT2ATDP1ALDH1A1 | |
| SCHEMBL13373156 | 0.78 | TDP1 (0.58) | LMNAL3MBTL1KMT2ATDP1ALDH1A1 | |
| SCHEMBL13373158 | 0.78 | LMNA (0.65) | LMNAKMT2AALDH1A1MEN1GAA | |
| SCHEMBL18031182 | 0.78 | LMNA (0.68) | LMNAL3MBTL1KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010007073-A1 | PIPERAZINE DERIVATIVES USED AS CAV2.2 CALCIUM CHANNEL MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-01-21 | — | — | WO | disclosed |