Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14506064 | 1.00 | CA12 (0.48) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL14269147 | 1.00 | CA12 (0.48) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL13512973 | 1.00 | CA12 (0.48) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL14506062 | 0.88 | CA12 (0.47) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL14532046 | 0.88 | CA12 (0.47) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL10950241 | 0.87 | SMN1; SMN2 (0.54) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL14531835 | 0.85 | CA12 (0.47) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL14506067 | 0.85 | CA12 (0.47) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL14040323 | 0.84 | GAA (0.46) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL5423574 | 0.82 | ALDH1A1 (0.47) | SMN1; SMN2KMT2AGAAALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817273-B1 | METHOD FOR PREPARING DIASTEREOISOMERS OF 4-HYDROXY ISOLEUCINE | CENTRE NAT RECH SCIENT (FR) | 2010-01-27 | — | — | EP | disclosed |
| EP-1620390-B1 | METHOD FOR THE SYNTHESIS OF 4-HYDROXYISOLEUCINE AND THE DERIVATIVES THEREOF | CENTRE NAT RECH SCIENT (FR) | 2008-10-01 | — | — | EP | disclosed |
| US-7326805-B2 | Method for the synthesis of 4-hydroxyisoleucine and the derivatives thereof | MIOSKOWSKI CHARLES | 2008-02-05 | — | — | US | disclosed |
| US-7326805-B2 | Method for the synthesis of 4-hydroxyisoleucine and the derivatives thereof | MIOSKOWSKI CHARLES | 2008-02-05 | — | — | US | disclosed |
| WO-2007062316-A2 | TRANS-3,5-DISUBSTITUTEDPYRROLIDINE: ORGANOCATALYST FOR ANTI-MANNICH REACTIONS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-05-31 | — | — | WO | disclosed |
| US-20070117986-A1 | TRANS-3,5-DISUBSTITUTEDPYRROLIDINE: ORGANOCATALYST FOR anti-MANNICH REACTIONS | THE SCRIPPS RESEARCH INSTITUTE | 2007-05-24 | — | — | US | disclosed |
| US-20070043240-A1 | Method for the synthesis of 4-hydroxyisoleucine and the derivatives thereof | MIOSKOWSKI CHARLES | 2007-02-22 | — | — | US | disclosed |
| US-20070043240-A1 | Method for the synthesis of 4-hydroxyisoleucine and the derivatives thereof | MIOSKOWSKI CHARLES | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117986-A1 | TRANS-3,5-DISUBSTITUTEDPYRROLIDINE: ORGANOCATALYST FOR anti-MANNICH REACTIONS | HRH4, NR1I3, NR1I2 | CA12 3214/4885CA1 1924/4885CA2 3375/4885 |
| US-20070043240-A1 | Method for the synthesis of 4-hydroxyisoleucine and the derivatives thereof | IL4I1, CBR3, CBR1 | CA12 1088/4885CA1 541/4885CA2 982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.