Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24781805 | 0.91 | GAA (0.49) | GAAMMP8PIN1CA12CA1 | |
| SCHEMBL23204363 | 0.91 | GAA (0.49) | GAAMMP8PIN1CA12CA1 | |
| SCHEMBL10952879 | 0.86 | GAA (0.50) | GAAMMP8PIN1CA12CA1 | |
| SCHEMBL29768237 | 0.86 | GAA (0.50) | GAAMMP8PIN1CA12CA1 | |
| SCHEMBL11203443 | 0.84 | GAA (0.49) | GAAMMP8PIN1CA12CA1 | |
| SCHEMBL14269147 | 0.84 | CA12 (0.48) | GAACA12CA1CA2CA9 | |
| SCHEMBL14506064 | 0.84 | CA12 (0.48) | GAACA12CA1CA2CA9 | |
| SCHEMBL13512971 | 0.84 | CA12 (0.48) | GAACA12CA1CA2CA9 | |
| SCHEMBL13512973 | 0.84 | CA12 (0.48) | GAACA12CA1CA2CA9 | |
| SCHEMBL9338686 | 0.80 | CA12 (0.54) | GAAMMP8PIN1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620390-B1 | METHOD FOR THE SYNTHESIS OF 4-HYDROXYISOLEUCINE AND THE DERIVATIVES THEREOF | CENTRE NAT RECH SCIENT (FR) | 2008-10-01 | — | — | EP | disclosed |
| US-7326805-B2 | Method for the synthesis of 4-hydroxyisoleucine and the derivatives thereof | MIOSKOWSKI CHARLES | 2008-02-05 | — | — | US | disclosed |
| US-7326805-B2 | Method for the synthesis of 4-hydroxyisoleucine and the derivatives thereof | MIOSKOWSKI CHARLES | 2008-02-05 | — | — | US | disclosed |
| US-20070043240-A1 | Method for the synthesis of 4-hydroxyisoleucine and the derivatives thereof | MIOSKOWSKI CHARLES | 2007-02-22 | — | — | US | disclosed |
| US-20070043240-A1 | Method for the synthesis of 4-hydroxyisoleucine and the derivatives thereof | MIOSKOWSKI CHARLES | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043240-A1 | Method for the synthesis of 4-hydroxyisoleucine and the derivatives thereof | IL4I1, CBR3, CBR1 | GAA 2725/4885MMP8 4675/4885PIN1 1926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.