Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14543949 | 0.77 | SMN1; SMN2 (0.35) | KMT2AMEN1SMN1; SMN2TP53MAPT | |
| SCHEMBL11674215 | 0.76 | SMN1; SMN2 (0.57) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2914537 | 0.75 | NAPRT (0.52) | NPC1RAB9AKMT2ASMN1; SMN2TP53 | |
| SCHEMBL10401175 | 0.74 | SMN1; SMN2 (0.80) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL21511125 | 0.74 | SMN1; SMN2 (0.59) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11238734 | 0.73 | SMN1; SMN2 (0.57) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL17211904 | 0.73 | RAB9A (0.58) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9811717 | 0.73 | RAB9A (0.58) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11679352 | 0.73 | SMN1; SMN2 (0.57) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL15791126 | 0.73 | RAB9A (0.58) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663211-B1 | AMINOTRIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2010-01-20 | — | — | EP | disclosed |