Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13549187 | 0.89 | FBP1 (0.48) | EGFRERBB2LMNA | |
| SCHEMBL13514657 | 0.84 | EGFR (0.57) | EGFRHTTHIF1A | |
| SCHEMBL13514762 | 0.84 | EGFR (0.47) | EGFRERBB2 | |
| SCHEMBL13514655 | 0.83 | ALDH1A1 (0.48) | EGFRHTTHIF1AERBB2MAPK1 | |
| SCHEMBL13549176 | 0.82 | EGFR (0.50) | EGFRERBB2 | |
| SCHEMBL1766099 | 0.77 | FBP1 (0.49) | EGFRERBB2LMNA | |
| SCHEMBL13514771 | 0.76 | ALDH1A1 (0.48) | EGFRHTTHIF1AERBB2MAPK1 | |
| SCHEMBL13549188 | 0.75 | EGFR (0.53) | EGFRERBB2LMNA | |
| SCHEMBL13514659 | 0.75 | EGFR (0.56) | EGFRERBB2LMNA | |
| SCHEMBL13549168 | 0.74 | EGFR (0.52) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002845-A2 | QUINAZOLINE DERIVATIVES | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2010-01-07 | — | — | WO | disclosed |