Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13549168 | 0.89 | EGFR (0.52) | EGFR | |
| SCHEMBL13514655 | 0.87 | ALDH1A1 (0.48) | EGFRHTTHIF1A | |
| SCHEMBL13514653 | 0.84 | EGFR (0.45) | EGFRHTTHIF1A | |
| SCHEMBL13514771 | 0.81 | ALDH1A1 (0.48) | EGFRHTTHIF1A | |
| SCHEMBL13514757 | 0.79 | EGFR (0.48) | EGFR | |
| SCHEMBL13549108 | 0.77 | EGFR (0.53) | EGFRKDRBRAFAURKAAURKB | |
| SCHEMBL13514763 | 0.76 | EGFR (0.46) | EGFRHTTHIF1A | |
| SCHEMBL13549233 | 0.76 | EGFR (0.49) | EGFRKDRBRAFAURKAAURKB | |
| SCHEMBL13549188 | 0.74 | EGFR (0.53) | EGFRKDRBRAFAURKAAURKB | |
| SCHEMBL13549187 | 0.74 | FBP1 (0.48) | EGFRKDRBRAFAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318378-B1 | QUINAZOLINE DERIVATIVES | HUTCHISON MEDIPHARMA ENTPR LTD (BS) | 2013-10-23 | — | — | EP | disclosed |
| WO-2010002845-A2 | QUINAZOLINE DERIVATIVES | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2010-01-07 | — | — | WO | disclosed |